Risk factors for the development of osteoarthritis in middle-aged women

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dc.contributor.authorBlumel, Juan E.
dc.contributor.authorAedo, Socrates
dc.contributor.authorArteaga, Eugenio
dc.contributor.authorVallejo, Maria S.
dc.contributor.authorChedraui, Peter
dc.date.accessioned2025-01-20T21:04:13Z
dc.date.available2025-01-20T21:04:13Z
dc.date.issued2022
dc.description.abstractBackground: Osteoarthritis (OA) is a health problem affecting millions of individuals worldwide. Aim: To evaluate risk factors for hip and knee osteoarthritis (OA) in women aged 40 to 59 years. Material and Methods: Analysis of a prospective cohort of 1159 women attending preventive health care programs and followed during 28 years. They underwent a clinical and laboratory evaluation from 1990 to 1993. The diagnosis of OA was retrieved from registries of a special program for osteoarthritis in 2020. Results: Twenty four percent of participants developed osteoarthritis during the follow-up. At the beginning of the study and compared with women without OA, they were older (median [interquartile range or IQR]: 49.6 [8.5] and 47.2 [8.2] years respectively), had a higher body mass index (26.3 [5.3] and 25.1 [5.3] respectively), and a higher frequency of jobs with low qualification (76 and 62% respectively). The presence of type 2 diabetes mellitus, chronic hypertension, a previous history of alcohol or cigarette consumption, postmenopausal status and lipid and glucose blood levels did not differ between women with or without OA. Cox regression showed a final model that incorporates body mass index (hazard ratio (HR): 1.04; 95% confidence intervals (CI): 1.01-1.07), age (HR: 1.05; 95% CI: 1.03-1.08) and having an unqualified job (HR: 1.88; 95% CI: 1.43-2.47) as risk factors for OA. Conclusions: Obesity and the type of job are the most relevant risk factors found for OD: both may be modified with proper care. (Rev Med Chile 2022; 150: 46-53)
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93223
dc.identifier.wosidWOS:000827225300005
dc.issue.numero1
dc.language.isoen
dc.pagina.final53
dc.pagina.inicio46
dc.revistaRevista medica de chile
dc.rightsacceso restringido
dc.subjectCohort Studies
dc.subjectObesity
dc.subjectOsteoarthritis
dc.subjectWomen
dc.subjectRisk Factors
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRisk factors for the development of osteoarthritis in middle-aged women
dc.typeartículo
dc.volumen150
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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