Clinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients

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dc.contributor.authorTorres, Ruben
dc.contributor.authorToro, Luis
dc.contributor.authorEugenia Sanhueza, Maria
dc.contributor.authorLorca, Eduardo
dc.contributor.authorOrtiz, Mireya
dc.contributor.authorPefaur, Jacqueline
dc.contributor.authorClavero, Rene
dc.contributor.authorMachuca, Eduardo
dc.contributor.authorGonzalez, Fernando
dc.contributor.authorHerrera, Patricia
dc.contributor.authorMocarquer, Alfredo
dc.contributor.authorFrias, Alondra
dc.contributor.authorRoessler, Eric
dc.contributor.authorMunoz, Carolina
dc.contributor.authorNunez, Miguel
dc.contributor.authorAravena, Cesar
dc.contributor.authorQuintana, Enrique
dc.contributor.authorLemus, Juan
dc.contributor.authorLillo, Mario
dc.contributor.authorReynolds, Enrique
dc.contributor.authorMorales, Alvaro
dc.contributor.authorPais, Edgard
dc.contributor.authorFiabane, Andrea
dc.contributor.authorParra-Lucares, Alfredo
dc.contributor.authorGarrido, Cristian
dc.contributor.authorMendez-Valdes, Gabriel
dc.contributor.authorVilla, Eduardo
dc.contributor.authorMansilla, Rodrigo
dc.contributor.authorSotomayor, Germana
dc.contributor.authorGonzalez, Marcela
dc.contributor.authorMiranda, Cecilia
dc.contributor.authorBriones, Eduardo
dc.contributor.authorGomez, Esteban
dc.contributor.authorMezzano, Sergio
dc.contributor.authorBernales, Waldo
dc.contributor.authorRocca, Ximena
dc.contributor.authorEspinoza, Oscar
dc.contributor.authorZuniga, Eric
dc.contributor.authorAragon, Henry
dc.contributor.authorBadilla, Marta
dc.contributor.authorValenzuela, Marcela
dc.contributor.authorEscobar, Luis
dc.contributor.authorZamora, Daniela
dc.contributor.authorFlores, Ivan
dc.contributor.authorTapia, Beatriz
dc.contributor.authorBorquez, Tamara
dc.contributor.authorHerrera, Patricio
dc.date.accessioned2025-01-20T21:00:52Z
dc.date.available2025-01-20T21:00:52Z
dc.date.issued2022
dc.description.abstractIntroduction: The COVID-19 pandemic is a global public health problem. Patients with end-stage renal disease on hemodialysis are at a higher risk of infection and mortality than the general population. Worldwide, a vaccination campaign has been developed that has been shown to reduce severe infections and deaths in the general population. However, there are currently limited data on the clinical efficacy of vaccinations in the hemodialysis population.
dc.description.abstractMethods: A national multicenter observational cohort was performed in Chile to evaluate the clinical efficacy of anti-SARS-CoV-2 vaccination in end-stage renal disease patients on chronic hemodialysis from February 2021 to August 2021. In addition, the BNT162b2 (Pfizer-BioNTech) and CoronaVac (Sinovac) vaccines were evaluated. The efficacy of vaccination in preventing SARS-CoV-2 infection, hospitalizations, and deaths associated with COVID-19 was determined.
dc.description.abstractResults: A total of 12,301 patients were evaluated; 10,615 (86.3%) received a complete vaccination (2 doses), 490 (4.0%) received incomplete vaccination, and 1196 (9.7%) were not vaccinated. During followup, 1362 (11.0%) patients developed COVID-19, and 150 died (case fatality rate: 11.0%). The efficacy of the complete vaccination in preventing infection was 18.1% (95% confidence interval [CI]:11.8-23.8%), and prevention of death was 66.0% (95% CI:60.6-70.7%). When comparing both vaccines, BNT162b2 and CoronaVac were effective in reducing infection and deaths associated with COVID-19. Nevertheless, the BNT162b2 vaccine had higher efficacy in preventing infection (42.6% vs. 15.0%) and deaths (90.4% vs. 64.8%) compared to CoronaVac.
dc.description.abstractConclusion: The results of our study suggest that vaccination against SARS-CoV-2 in patients on chronic hemodialysis was effective in preventing infection and death associated with COVID-19.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ekir.2022.07.007
dc.identifier.issn2468-0249
dc.identifier.urihttps://doi.org/10.1016/j.ekir.2022.07.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92755
dc.identifier.wosidWOS:000927846700007
dc.issue.numero10
dc.language.isoen
dc.pagina.final2185
dc.pagina.inicio2176
dc.revistaKidney international reports
dc.rightsacceso restringido
dc.subjectCOVID-19
dc.subjectepidemiology
dc.subjecthemodialysis
dc.subjectmortality
dc.subjectrenal dialysis
dc.subjectSARS-CoV-2
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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