Pathophysiology of fuid administration in critically ill patients

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dc.article.number46
dc.contributor.authorMessina, Antonio
dc.contributor.authorBakker, Jan
dc.contributor.authorChew, Michelle
dc.contributor.authorDe Backer, Daniel
dc.contributor.authorHamzaoui, Olfa
dc.contributor.authorHernández P., Glenn
dc.contributor.authorMyatra, Sheila N.
dc.contributor.authorMonnet, Xavier
dc.contributor.authorOstermann, Marlies
dc.contributor.authorPinsky, Michael
dc.contributor.authorTeboul, Jean-Louis
dc.contributor.authorCecconi, Maurizio
dc.date.accessioned2022-11-15T15:41:10Z
dc.date.available2022-11-15T15:41:10Z
dc.date.issued2022
dc.date.updated2022-11-06T01:02:35Z
dc.description.abstractFluid administration is a cornerstone of treatment of critically ill patients. The aim of this review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms related to the interplay of flow and pressure variables, the systemic response to the shock syndrome, the effects of different types of fluids administered and the concept of preload dependency responsiveness. In this context, the relationship between preload, stroke volume (SV) and fluid administration is that the volume infused has to be large enough to increase the driving pressure for venous return, and that the resulting increase in end-diastolic volume produces an increase in SV only if both ventricles are operating on the steep part of the curve. As a consequence, fluids should be given as drugs and, accordingly, the dose and the rate of administration impact on the final outcome. Titrating fluid therapy in terms of overall volume infused but also considering the type of fluid used is a key component of fluid resuscitation. A single, reliable, and feasible physiological or biochemical parameter to define the balance between the changes in SV and oxygen delivery (i.e., coupling “macro” and “micro” circulation) is still not available, making the diagnosis of acute circulatory dysfunction primarily clinical.
dc.format.extent15 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationIntensive Care Medicine Experimental. 2022 Nov 04;10(1):46
dc.identifier.doi10.1186/s40635-022-00473-4
dc.identifier.urihttps://doi.org/10.1186/s40635-022-00473-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/65581
dc.identifier.wosidWOS:000878653100001
dc.information.autorucEscuela de medicina ; Hernández P., Glenn ; 0000-0002-3032-4087 ; 98874
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final15
dc.pagina.inicio1
dc.revistaIntensive Care Medicine Experimental
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePathophysiology of fuid administration in critically ill patientses_ES
dc.typeartículo
dc.volumen10
sipa.codpersvinculados98874
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