Milrinone as a Rescue Therapy for Symptomatic Refractory Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage

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dc.contributor.authorRomero, C. M.
dc.contributor.authorMorales, D.
dc.contributor.authorReccius, A.
dc.contributor.authorMena, F.
dc.contributor.authorPrieto, J.
dc.contributor.authorBustos, P.
dc.contributor.authorLarrondo, J.
dc.contributor.authorCastro, J.
dc.date.accessioned2025-01-21T00:08:03Z
dc.date.available2025-01-21T00:08:03Z
dc.date.issued2009
dc.description.abstractDelayed ischemic neurological deficit associated to cerebral vasospasm is the most common cause of sequelae and death that follows the rupture of an aneurysm. The objective of this study was to evaluate the safety and efficacy of intra-arterial Milrinone in patients with symptomatic refractory cerebral vasospasm.
dc.description.abstractEight patients diagnosed with aneurysmal subarachnoid hemorrhage who developed symptomatic cerebral vasospasm refractory to conventional medical therapy were enrolled. They received an intra-arterial infusion of Milrinone at a rate of 0.25 mg/min, with a total dose of 10-15 mg. Qualitative evaluation of angiographic response, neurological and systemic complications as well as functional outcome at 3 months were documented.
dc.description.abstractAll patients had a significant angiographic response. This was evidenced by a pre-treatment vessel stenosis greater than 70%, that improved to less than 50% after the intra-arterial Milrinone infusion. Three patients developed recurrent vasospasm that improved after a second intra-arterial Milrinone infusion. None of the patients developed neurologic or systemic complications attributed to the intervention. At 3 months follow-up all patients were alive and had a mean modified Rankin scale of 2 +/- A 1 and a Barthel index of 83 +/- A 10.
dc.description.abstractIntra-arterial Milrinone infusion seems to be a safe and effective treatment for patients who develop refractory symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12028-008-9048-0
dc.identifier.eissn1556-0961
dc.identifier.issn1541-6933
dc.identifier.urihttps://doi.org/10.1007/s12028-008-9048-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95654
dc.identifier.wosidWOS:000269902300006
dc.issue.numero2
dc.language.isoen
dc.pagina.final171
dc.pagina.inicio165
dc.revistaNeurocritical care
dc.rightsacceso restringido
dc.subjectSubarachnoid hemorrhage
dc.subjectCerebral vasospasm
dc.subjectMilrinone
dc.subjectCerebrovascular disease
dc.subjectAneurysm rupture
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMilrinone as a Rescue Therapy for Symptomatic Refractory Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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