Plants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study

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dc.catalogadoryvc
dc.contributor.authorGonzález Itier, Sergio Andrés
dc.contributor.authorMiranda, Miguel
dc.contributor.authorCorrales‐Orovio, Rocío
dc.contributor.authorVera, Constanza
dc.contributor.authorVeloso‐Giménez, Valentina
dc.contributor.authorCárdenas Calderón, Camila Valentina
dc.contributor.authorEgaña, José Tomás
dc.date.accessioned2024-04-03T13:51:55Z
dc.date.available2024-04-03T13:51:55Z
dc.date.issued2024
dc.description.abstractOxygen is essential for tissue regeneration, playing a crucial role in several processes, including cell metabolism and immune response. Therefore, the delivery of oxygen to wounds is an active field of research, and recent studies have highlighted the potential use of photosynthetic biomaterials as alternative oxygenation approach. However, while plants have traditionally been used to enhance tissue regeneration, their potential to produce and deliver local oxygen to wounds has not yet been explored. Hence, in this work we studied the oxygen-releasing capacity of Marchantia polymorpha explants, showing their capacity to release oxygen under different illumination settings and temperatures. Moreover, co-culture experiments revealed that the presence of these explants had no adverse effects on the viability and morphology of fibroblasts in vitro, nor on the viability of zebrafish larvae in vivo. Furthermore, oxygraphy assays demonstrate that these explants could fulfill the oxygen metabolic requirements of zebrafish larvae and freshly isolated skin biopsies ex vivo. Finally, the biocompatibility of explants was confirmed through a human skin irritation test conducted in healthy volunteers following the ISO-10993-10-2010. This proof-of-concept study provides valuable scientific insights, proposing the potential use of freshly isolated plants as biocompatible low-cost oxygen delivery systems for wound healing and tissue regeneration.
dc.description.funderANID/Fondecyt 1200280 (to JTE) and Scholarship 21180821 (to SG‐I)
dc.fechaingreso.objetodigital2024-04-03
dc.format.extent12 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1002/bit.28705
dc.identifier.eissn1097-0290
dc.identifier.issn0006-3592
dc.identifier.urihttps://doi.org/10.1002/bit.28705
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84910
dc.identifier.wosidWOS:001193829700001
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Egaña Erazo, Jose Tomas; 0000-0003-2624-6992; 1018715
dc.information.autorucFacultad de Ciencias Biológicas; Cárdenas Calderón, Camila Valentina; S/I; 195529
dc.information.autorucEscuela de Ingeniería; Gonzalez Itier, Sergio Andres; 0000-0003-0097-7498; 1070568
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaBiotechnology and Bioengineering
dc.rightsacceso restringido
dc.subjectMarchantia polymorpha
dc.subjectOxygen
dc.subjectPhotosynthetic biomaterial
dc.subjectWound heal
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods06 Clean water and sanitation
dc.subject.odspa06 Agua limpia y saneamiento
dc.titlePlants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study
dc.typeartículo
sipa.codpersvinculados1018715
sipa.codpersvinculados195529
sipa.codpersvinculados1070568
sipa.trazabilidadORCID;2024-04-01
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