Females of the communally breeding rodent, <i>Octodon degus</i>, transfer antibodies to their offspring during pregnancy and lactation

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dc.contributor.authorBecker, Maria Ines
dc.contributor.authorDe Ioannes, Alfredo E.
dc.contributor.authorLeon, Cecilia
dc.contributor.authorEbensperger, Luis A.
dc.date.accessioned2025-01-21T01:05:31Z
dc.date.available2025-01-21T01:05:31Z
dc.date.issued2007
dc.description.abstractFemales in numerous rodent species engage in communal nesting and breeding, meaning that they share a nest to rear their young together. One potential benefit to communally nesting mot-hers is that infants improve their immunocompetence. Thus, suckling from two or more females might provide newborns with a more diverse array of antibodies and defensive cells. As a first step toward testing the immunocompetence hypothesis, we assessed whether female degus (Octodon degus), a communally nesting and breeding caviomorph rodent, transfer immunoglobulins to their young through the yolk sac or placenta while in the uterus and,during lactation, through milk. With this aim, adult degu females were immunized with four antigens, including two mollusk hemocyanins from Concholepas and Megathura (CCH and KLH, respectively), porcine thyroglobulin and tetanus toxoid. Specific antibodies against,the experimental antigens were used to track the origin of antibodies in the young. To establish the presence of specific antibodies of IgG and IgA isotypes in sera and milk of animals, an indirect enzyme-linked immunosorbent assay (ELISA) was developed. Degu females produced specific antibodies against antigens not found in their natural environment, and mothers were able to transfer the induced antibodies to their litters during pregnancy (IgG) and during lactation (IgA). However, we recorded only limited evidence of degu offspring acquiring antibodies from lactating mothers other than their own, giving little support to the increased immunocompetence hypothesis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jri.2007.01.002
dc.identifier.issn0165-0378
dc.identifier.urihttps://doi.org/10.1016/j.jri.2007.01.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95945
dc.identifier.wosidWOS:000247053900009
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final77
dc.pagina.inicio68
dc.revistaJournal of reproductive immunology
dc.rightsacceso restringido
dc.subjectcommunal nesting and breeding
dc.subjectimmunity transfer
dc.subjectimmunoglobulins
dc.subjectpregnancy
dc.subjectlactation
dc.subjectdegus
dc.subject.ods13 Climate Action
dc.subject.ods15 Life on Land
dc.subject.odspa13 Acción por el clima
dc.subject.odspa15 Vida de ecosistemas terrestres
dc.titleFemales of the communally breeding rodent, <i>Octodon degus</i>, transfer antibodies to their offspring during pregnancy and lactation
dc.typeartículo
dc.volumen74
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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