Effectiveness of varicella vaccine as post exposure prophylaxis in Chilean children

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dc.contributor.authorPinochet, Constanza
dc.contributor.authorCerda, Jaime
dc.contributor.authorHirsch, Tamara
dc.contributor.authorMieres, Jocelyn
dc.contributor.authorInostroza, Carolina
dc.contributor.authorAbarca, Katia
dc.date.accessioned2024-01-10T12:05:05Z
dc.date.available2024-01-10T12:05:05Z
dc.date.issued2012
dc.description.abstractEffectiveness of varicella vaccine as post exposure prophylaxis in Chilean children Introduction: Efficacy and effectiveness of varicella vaccine (VV) as post exposure prophylaxis (PEP) strategy have shown discordant results for disease risk reduction, and more consistent results in their ability to attenuate the disease. Aim: To assess the effectiveness of VV as PEP among household contacts. Material and Methods: We followed up 33 children after household exposure to a varicella case, of which 15 received VV as PEP and 18 did not received VV. The presence and severity of the disease were clinically determined. Results: Secondary attack rate was 53% among vaccinated and 89% among non-vaccinated children. Overall effectiveness of VV as PEP was 40% (CI95% 1%-64%). The effectiveness for preventing moderate or severe disease was 63% (CI95% 8%-85%) in the entire group and 77% (CI95% 14%-94%) among children vaccinated during the first 3 days post exposure. Vaccine tolerance was acceptable, with a low number of adverse reactions, all of them mild. Conclusion: The results suggest that VV as PEP is effective among household contacts, especially for reducing the severity of the disease.
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0716-10182012000700008
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:23412032
dc.identifier.urihttps://doi.org/10.4067/S0716-10182012000700008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75943
dc.identifier.wosidWOS:000312684700008
dc.information.autorucMedicina;Abarca K ;S/I;70281
dc.information.autorucMedicina;Cerda J;S/I;3935
dc.information.autorucMedicina;Hirsch T ;S/I;99387
dc.information.autorucMedicina;Inostroza C ;S/I;156263
dc.information.autorucMedicina;Mieres J ;S/I;131888
dc.information.autorucMedicina;Pinochet C ;S/I;190227
dc.issue.numero6
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final640
dc.pagina.inicio635
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsacceso abierto
dc.subjectVaricella
dc.subjectvaricella vaccine
dc.subjectpost exposure prophylaxis
dc.subjectIMMEDIATE INOCULATION
dc.subjectSAFETY PROFILE
dc.subjectPOSTEXPOSURE
dc.subjectCONTACTS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffectiveness of varicella vaccine as post exposure prophylaxis in Chilean children
dc.typeartículo
dc.volumen29
sipa.codpersvinculados70281
sipa.codpersvinculados3935
sipa.codpersvinculados99387
sipa.codpersvinculados156263
sipa.codpersvinculados131888
sipa.codpersvinculados190227
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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