Vernix caseosa reveals mechanistic clues linking maternal obesity to atopic dermatitis pathogenesis

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dc.catalogadorjlo
dc.contributor.authorArenas Cabalín, Carolina Andrea
dc.contributor.authorDibarrart Duhalde, Marisol
dc.contributor.authorNúñez Rosales, Juan José
dc.contributor.authorFaunes Pérez, Miriam Elizabeth
dc.contributor.authorAvaca Bengochea, Mónica
dc.contributor.authorÁvalos Odano, Patricia De Las Mercedes
dc.contributor.authorFabres Biggs, Jorge Guillermo Eduardo
dc.contributor.authorÁlvarez Figueroa, María Javiera
dc.contributor.authorVera Kellet, Cristián Andrés
dc.contributor.authorSilva Valenzuela, Sergio
dc.contributor.authorSáez Steeger, Claudia
dc.contributor.authorBorzutzky Schachter, Arturo José
dc.date.accessioned2023-12-29T14:29:24Z
dc.date.available2023-12-29T14:29:24Z
dc.date.issued2023
dc.description.abstractBackground Maternal overweight and obesity have been associated with an increased risk of atopic dermatitis (AD) in the offspring, but the underlying mechanisms are unclear. Vernix caseosa (VC) is a proteolipid material covering the fetus produced during skin development. However, whether maternal prepregnancy weight excess influences fetal skin development is unknown. Characterizing the VC of newborns from mothers with prepregnancy overweight and obesity might reveal AD-prone alterations during fetal skin development.ObjectiveWe sought to explore AD biomarkers and staphylococcal loads in VC from the offspring of mothers who were overweight/obese (O/O) before pregnancy versus in those from offspring of normal weight mothers.MethodsThe VC of newborns of 14 O/O and 12 normal weight mothers were collected immediately after birth. Biomarkers were determined by ELISA and staphylococcal species by quantitative PCR.ResultsThe VC from the O/O group showed decreased expression of skin barrier proteins (filaggrin and loricrin) and increased levels of proinflammatory biomarkers (IgA, thymic stromal lymphopoietin [TSLP], S100A8, IL-25, and IL-33). No differences in concentrations of antimicrobial peptides and enzymes were detected. The VC from the O/O group had a lower Staphylococcus epidermidis and Staphylococcus hominis commensal bacterial load, whereas Staphylococcus aureus bacterial load was not significantly different between the 2 groups. Maternal body mass index was negatively correlated with VC filaggrin expression and S epidermidis load and was positively associated with TSLP concentration. One-year follow-up established that the offspring of O/O mothers had a higher incidence of AD that was specifically linked with decreased VC filaggrin expression and lower S epidermidis load.ConclusionsVC from neonates of mothers with prepregnancy overweight and obesity exhibit skin barrier molecular alterations and staphylococcal dysbiosis that suggest early mechanistic clues to this population’s increased risk of AD.
dc.fechaingreso.objetodigital2023-12-29
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.jaci.2023.09.042
dc.identifier.issn1097-6825
dc.identifier.urihttp://dx.doi.org/10.1016/j.jaci.2023.09.042
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75586
dc.information.autorucEscuela de Medicina; Arenas Cabalín, Carolina Andrea; 0000-0001-6344-3966; 187036
dc.information.autorucEscuela de Medicina; Dibarrart Duhalde, Marisol; S/I; 63149
dc.information.autorucFacultad de Ciencias Biológicas; Nuñez Rosales, Juan José; S/I; 1066809
dc.information.autorucEscuela de Enfermería; Faunes Pérez, Miriam Elizabeth; 0000-0002-0052-1100; 65736
dc.information.autorucEscuela de Enfermería; Avaca Bengochea, Mónica; S/I; 68109
dc.information.autorucEscuela de Enfermería; Ávalos Odano, Patricia De Las Mercedes; S/I; 72084
dc.information.autorucEscuela de Medicina; Fabres Biggs, Jorge Guillermo Eduardo; 0000-0003-0217-2378; 71713
dc.information.autorucEscuela de Química; Álvarez Figueroa, María Javiera; 0000-0001-5911-7543; 70358
dc.information.autorucEscuela de Medicina; Vera Kellet, Cristián Andrés; 0000-0001-8697-9245; 9379
dc.information.autorucEscuela de Medicina; Silva Valenzuela, Sergio; S/I; 100119
dc.information.autorucEscuela de Medicina; Sáez Steeger, Claudia; 0000-0001-7183-1491; 102375
dc.information.autorucEscuela de Medicina; Borzutzky Schachter, Arturo José; 0000-0002-7904-262X; 5897
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final9
dc.pagina.inicio1
dc.revistaJournal of Allergy and Clinical Immunology
dc.rightsacceso restringido
dc.subjectAtopic dermatitis
dc.subjectVernix caseosa
dc.subjectMaternal obesity
dc.subjectSkin barrier
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.ods02 Zero hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleVernix caseosa reveals mechanistic clues linking maternal obesity to atopic dermatitis pathogenesis
dc.typeartículo
sipa.codpersvinculados187036
sipa.codpersvinculados63149
sipa.codpersvinculados1066809
sipa.codpersvinculados65736
sipa.codpersvinculados68109
sipa.codpersvinculados72084
sipa.codpersvinculados71713
sipa.codpersvinculados70358
sipa.codpersvinculados9379
sipa.codpersvinculados100119
sipa.codpersvinculados102375
sipa.codpersvinculados5897
sipa.trazabilidadORCID;2023-12-25
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