Cell segregation and boundary formation during nervous system development

Simple item page
dc.contributor.authorConstanza Gonzalez-Ramirez, M.
dc.contributor.authorGuzman-Palma, Pablo
dc.contributor.authorOliva, Carlos
dc.date.accessioned2025-01-20T23:51:24Z
dc.date.available2025-01-20T23:51:24Z
dc.date.issued2021
dc.description.abstractThe development of multicellular organisms involves three main events: differentiation, growth, and morphogenesis. These processes need to be coordinated for a correct developmental program to work. Mechanisms of cell segregation and the formation of boundaries during development play essential roles in this coordination, allowing the generation and maintenance of distinct regions in an organism.These mechanisms are also at work in the nervous system. The process of regionalization involves first the patterning of the developing organism through gradients and the expression of transcription factors in specific regions. Once different tissues have been induced, segregation mechanisms may operate to avoid cell mixing between different compartments.Three mechanisms have been proposed to achieve segregation: (1) differential affinity, which mainly involves the expression of distinct pools of adhesion molecules such as members of the cadherin superfamily; (2) contact inhibition, which is largely mediated by Eph-ephrin signaling; and (3) cortical tension, which involves the actomyosin cytoskeleton. In many instances, these mechanisms collaborate in cell segregation. In the last three decades, there have been several advances in our understanding of how cell segregation and boundaries participate in the development of the nervous system. Interestingly, as in other aspects of development, the molecular players are remarkably similar between vertebrates and invertebrates. Here we summarize the main concepts of cell segregation and boundary formation, focusing on the nervous system and highlighting the similarities between vertebrate and invertebrate model organisms.
dc.description.funderCONICYT
dc.fuente.origenWOS
dc.identifier.doi10.1387/ijdb.200148co
dc.identifier.eissn1696-3547
dc.identifier.issn0214-6282
dc.identifier.urihttps://doi.org/10.1387/ijdb.200148co
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94806
dc.identifier.wosidWOS:000631909900009
dc.issue.numero4-6
dc.language.isoen
dc.pagina.final261
dc.pagina.inicio251
dc.revistaInternational journal of developmental biology
dc.rightsacceso restringido
dc.subjectnervous system
dc.subjectboundary formation
dc.subjectcell segregation
dc.subjectdifferential affinity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCell segregation and boundary formation during nervous system development
dc.typeartículo
dc.volumen65
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas