Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

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dc.contributor.authorMarlevi, David
dc.contributor.authorMariscal-Harana, Jorge
dc.contributor.authorBurris, Nicholas S.
dc.contributor.authorSotelo, Julio
dc.contributor.authorRuijsink, Bram
dc.contributor.authorHadjicharalambous, Myrianthi
dc.contributor.authorAsner, Liya
dc.contributor.authorSammut, Eva
dc.contributor.authorChabiniok, Radomir
dc.contributor.authorUribe, Sergio
dc.contributor.authorWinter, Reidar
dc.contributor.authorLamata, Pablo
dc.contributor.authorAlastruey, Jordi
dc.contributor.authorNordsletten, David
dc.date.accessioned2025-01-20T22:01:27Z
dc.date.available2025-01-20T22:01:27Z
dc.date.issued2022
dc.description.abstractVentricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12265-021-10181-1
dc.identifier.eissn1937-5395
dc.identifier.issn1937-5387
dc.identifier.urihttps://doi.org/10.1007/s12265-021-10181-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93831
dc.identifier.wosidWOS:000728430600001
dc.issue.numero4
dc.language.isoen
dc.pagina.final707
dc.pagina.inicio692
dc.revistaJournal of cardiovascular translational research
dc.rightsacceso restringido
dc.subjectDilated cardiomyopathy
dc.subjectAortic hemodynamics
dc.subjectAortic relative pressure
dc.subjectAortic stiffness
dc.subject4D flow MRI
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAltered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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