Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats

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dc.contributor.authorQuezada, Claudia
dc.contributor.authorAlarcon, Sebastian
dc.contributor.authorCarcamo, Juan G.
dc.contributor.authorYanez, Alejandro
dc.contributor.authorCasanello, Paola
dc.contributor.authorSobrevia, Luis
dc.contributor.authorSan Martin, Rody
dc.date.accessioned2024-01-10T12:39:41Z
dc.date.available2024-01-10T12:39:41Z
dc.date.issued2011
dc.description.abstractOxidative stress has been linked to the podocytopathy, mesangial expansion and progression of diabetic nephropathy. The major cell defence mechanism against oxidative stress is reduced glutathione (GSH). Some ABC transporters have been shown to extrude GSH, oxidised glutathione or their conjugates out of the cell, thus implying a role for these transporters in GSH homeostasis. We found a remarkable expression of mRNA for multidrug resistance-associated proteins (MRP/ABCC) 1, 3, 4 and 5 in rat glomeruli. Three weeks after induction of diabetes in glomeruli of streptozotocin-treated rats, we observed a decline in reduced GSH levels and an increase in the expression and activity of MRP1 (ABCC1). These lower GSH levels were improved by ex vivo treatment with pharmacological inhibitors of MRP1 activity (MK571). We conclude that increased activity of MRP1 in diabetic glomeruli is correlated with an inadequate adaptive response to oxidative stress.
dc.description.funderFONDECYT (Chile)
dc.description.funderPIA-CONICYT (Chile)
dc.description.funderUniversidad Austral de Chile (Chile)
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1515/BC.2011.052
dc.identifier.eissn1437-4315
dc.identifier.issn1431-6730
dc.identifier.pubmedidMEDLINE:21495913
dc.identifier.urihttps://doi.org/10.1515/BC.2011.052
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77222
dc.identifier.wosidWOS:000290715200005
dc.information.autorucMedicina;Casanello P ;S/I;146772
dc.information.autorucMedicina;Sobrevia L ;S/I;1002656
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final537
dc.pagina.inicio529
dc.publisherWALTER DE GRUYTER GMBH
dc.revistaBIOLOGICAL CHEMISTRY
dc.rightsregistro bibliográfico
dc.subjectdiabetes
dc.subjectglomerulus
dc.subjectglutathione
dc.subjectmultidrug resistance
dc.subjectmultidrug resistance-associated protein 1 (MRP1)
dc.subjectpodocytes
dc.subjectP-GLYCOPROTEIN EXPRESSION
dc.subjectCONJUGATE EXPORT PUMP
dc.subjectABC-TRANSPORTERS
dc.subjectOXIDATIVE STRESS
dc.subjectADVANCED GLYCATION
dc.subjectPROXIMAL TUBULES
dc.subjectNAD(P)H OXIDASE
dc.subjectGLUTATHIONE
dc.subjectGENE
dc.subjectMODULATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIncreased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats
dc.typeartículo
dc.volumen392
sipa.codpersvinculados146772
sipa.codpersvinculados1002656
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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