Leuprolide acetate gonadotrophin response patterns during female puberty

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dc.contributor.authorMartinez Aguayo, A.
dc.contributor.authorHernandez, M. I.
dc.contributor.authorCapurro, T.
dc.contributor.authorPena, V.
dc.contributor.authorAvila, A.
dc.contributor.authorSalazar, T.
dc.contributor.authorAsenjo, S.
dc.contributor.authorIniguez, G.
dc.contributor.authorMericq, V.
dc.date.accessioned2024-01-10T13:49:56Z
dc.date.available2024-01-10T13:49:56Z
dc.date.issued2010
dc.description.abstractP>Objective
dc.description.abstractTo assess normative data and the usefulness of spontaneous and LHRH analogue-stimulated serum LH and FSH levels measured by immunoradiometric assays (IRMA) in the evaluation of normal puberty.
dc.description.abstractDesign
dc.description.abstractProspective. Healthy girls in Tanner I and Tanner II from the local community were invited to participate (n = 47).
dc.description.abstractMethods
dc.description.abstractA leuprolide acetate test (500 mcg/m2; sc) was performed. LH and FSH levels were determined using IRMA. Tanner II girls were assessed every 6 months until Tanner V. Girls who progressed from Tanner II to Tanner III in the next 6 months were called Tanner II-2; otherwise, they were called Tanner II-1.
dc.description.abstractResults
dc.description.abstractThe prepubertal upper limit (CI 95%) was 0 center dot 49 IU/l for basal LH and 5 center dot 1 IU/l for stimulated LH. Taking into account these LH cut-off limits, 72 center dot 2% and 66 center dot 7% of Tanner II-1 and 41 center dot 6% and 41 center dot 7% of Tanner II-2 subjects presented overlapping values for basal and stimulated LH, respectively, as compared with the Tanner I group. The cut-offs for basal and stimulated LH to predict progression from Tanner II to Tanner III in the next 6 months were a basal LH level >= 0 center dot 49 IU/l (Sensitivity = 0 center dot 58; 1-Specificity = 0 center dot 33) and a poststimulated LH level >= 4 center dot 75 IU/l (Sensitivity = 0 center dot 67; 1-Specificity = 0 center dot 44).
dc.description.abstractConclusion
dc.description.abstractAccording to an IRMA, the basal and leuprolide acetate gonadotrophin response patterns during the beginning stages of puberty overlapped between Tanner I and Tanner II, and the cut-offs of basal and stimulated LH levels to predict progress from Tanner II to Tanner III had low sensitivities for the following 6 months.
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1365-2265.2009.03735.x
dc.identifier.eissn1365-2265
dc.identifier.issn0300-0664
dc.identifier.pubmedidMEDLINE:19863573
dc.identifier.urihttps://doi.org/10.1111/j.1365-2265.2009.03735.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79492
dc.identifier.wosidWOS:000275180700010
dc.information.autorucMedicina;Martínez-Aguayo A;S/I;1003862
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final495
dc.pagina.inicio489
dc.publisherWILEY
dc.revistaCLINICAL ENDOCRINOLOGY
dc.rightsacceso restringido
dc.subjectCENTRAL PRECOCIOUS PUBERTY
dc.subjectLUTEINIZING-HORMONE
dc.subjectPREMATURE PUBARCHE
dc.subjectGIRLS
dc.subjectCHILDREN
dc.subjectASSAYS
dc.subjectDISORDERS
dc.subjectDIAGNOSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLeuprolide acetate gonadotrophin response patterns during female puberty
dc.typeartículo
dc.volumen72
sipa.codpersvinculados1003862
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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