Efficient non-contrast enhanced 3D Cartesian cardiovascular magnetic resonance angiography of the thoracic aorta in 3 min

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dc.contributor.authorFotaki, Anastasia
dc.contributor.authorMunoz, Camila
dc.contributor.authorEmanuel, Yaso
dc.contributor.authorHua, Alina
dc.contributor.authorBosio, Filippo
dc.contributor.authorKunze, Karl P.
dc.contributor.authorNeji, Radhouene
dc.contributor.authorMasci, Pier Giorgio
dc.contributor.authorBotnar, Rene M.
dc.contributor.authorPrieto, Claudia
dc.date.accessioned2025-01-20T22:01:01Z
dc.date.available2025-01-20T22:01:01Z
dc.date.issued2022
dc.description.abstractBackground: The application of cardiovascular magnetic resonance angiography (CMRA) for the assessment of thoracic aortic disease is often associated with prolonged and unpredictable acquisition times and residual motion artefacts. To overcome these limitations, we have integrated undersampled acquisition with image-based navigators and inline non-rigid motion correction to enable a free-breathing, contrast-free Cartesian CMRA framework for the visualization of the thoracic aorta in a short and predictable scan of 3 min.
dc.description.abstractMethods: 35 patients with thoracic aortic disease (36 +/- 13y, 14 female) were prospectively enrolled in this singlecenter study. The proposed 3D T2-prepared balanced steady state free precession (bSSFP) sequence with imagebased navigator (iNAV) was compared to the clinical 3D T2-prepared bSSFP with diaphragmatic-navigator gating (dNAV), in terms of image acquisition time. Three cardiologists blinded to iNAV vs. dNAV acquisition, recorded image quality scores across four aortic segments and their overall diagnostic confidence. Contrast ratio (CR) and relative standard deviation (RSD) of signal intensity (SI) in the corresponding segments were estimated. Co-axial aortic dimensions in six landmarks were measured by two readers to evaluate the agreement between the two methods, along with inter-observer and intra-observer agreement. Kolmogorov-Smirnov test, Mann-Whitney U (MWU), Bland-Altman analysis (BAA), intraclass correlation coefficient (ICC) were used for statistical analysis.
dc.description.abstractResults: The scan time for the iNAV-based approach was significantly shorter (3.1 +/- 0.5 min vs. 12.0 +/- 3.0 min for dNAV, P = 0.005). Reconstruction was performed inline in 3.0 +/- 0.3 min. Diagnostic confidence was similar for the proposed iNAV versus dNAV for all three reviewers (Reviewer 1: 3.9 +/- 0.3 vs. 3.8 +/- 0.4, P = 0.7; Reviewer 2: 4.0 +/- 0.2 vs. 3.9 +/- 0.3, P = 0.4; Reviewer 3: 3.8 +/- 0.4 vs. 3.7 +/- 0.6, P = 0.3). The proposed method yielded higher image quality scores in terms of artefacts from respiratory motion, and non-diagnostic images due to signal inhomogeneity were observed less frequently. While the dNAV approach outperformed the iNAV method in the CR assessment, the iNAV sequence showed improved signal homogeneity along the entire thoracic aorta [RSD SI 5.1 (4.4, 6.5) vs. 6.5 (4.6, 8.6), P = 0.002]. BAA showed a mean difference of < 0.05 cm across the 6 landmarks between the two datasets. ICC showed excellent inter- and intra-observer reproducibility.
dc.description.abstractConclusions: Thoracic aortic iNAV-based CMRA with fast acquisition (similar to 3 min) and inline reconstruction (3 min) is proposed, resulting in high diagnostic confidence and reproducible aortic measurements.
dc.fuente.origenWOS
dc.identifier.doi10.1186/s12968-021-00839-9
dc.identifier.eissn1532-429X
dc.identifier.issn1097-6647
dc.identifier.urihttps://doi.org/10.1186/s12968-021-00839-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93789
dc.identifier.wosidWOS:000740644300001
dc.issue.numero1
dc.language.isoen
dc.revistaJournal of cardiovascular magnetic resonance
dc.rightsacceso restringido
dc.subjectUndersampled Cartesian MRA
dc.subjectiNAV
dc.subjectThoracic aortic disease
dc.subjectNon-rigid motion correction
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEfficient non-contrast enhanced 3D Cartesian cardiovascular magnetic resonance angiography of the thoracic aorta in 3 min
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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