Quantitative EEG Correlates of Low Cerebral Perfusion in Severe Stroke

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dc.contributor.authorDiedler, Jennifer
dc.contributor.authorSykora, Marek
dc.contributor.authorBast, Thomas
dc.contributor.authorPoli, Sven
dc.contributor.authorVeltkamp, Roland
dc.contributor.authorMellado, Patricio
dc.contributor.authorSteiner, Thorsten
dc.contributor.authorRupp, Andre
dc.date.accessioned2025-01-21T00:08:02Z
dc.date.available2025-01-21T00:08:02Z
dc.date.issued2009
dc.description.abstractContinuous EEG provides the unique possibility to monitor neuronal function non-invasively. In our pilot study, we evaluated EEG spectral power during spontaneous drops in cerebral perfusion pressure (CPP) in deeply sedated and mechanically ventilated patients with severe stroke. We aimed to identify parameters that may be used for continuous monitoring even in patients with a burst-suppression baseline EEG pattern.
dc.description.abstractTwenty ventilated and sedated patients with severe hemorrhagic or ischemic stroke underwent continuous EEG monitoring with synchronous CPP recording.
dc.description.abstractEEG monitoring duration was 83.9 hours on average per patient. Spectral power of EEG during drops of CPP was compared with epochs during normal CPP under the same levels of sedation. We found a significant decrease in faster EEG activity (3.5-20.7 Hz) during phases of low CPP (unaffected hemisphere P < 0.01, affected hemisphere P < 0.01, both P < 0.01).
dc.description.abstractDespite considerable changes in baseline activity due to deep sedation and severe brain injury, we found evidence for disturbed neuronal function during drops in CPP. Thus, continuous EEG monitoring may add clinically relevant information on neuronal function in the setting of multimodality brain monitoring. Further studies are needed to implement real-time data analysis in the ICU setting.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12028-009-9236-6
dc.identifier.eissn1556-0961
dc.identifier.issn1541-6933
dc.identifier.urihttps://doi.org/10.1007/s12028-009-9236-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95653
dc.identifier.wosidWOS:000269902300012
dc.issue.numero2
dc.language.isoen
dc.pagina.final216
dc.pagina.inicio210
dc.revistaNeurocritical care
dc.rightsacceso restringido
dc.subjectContinuous EEG
dc.subjectMultimodality brain monitoring
dc.subjectCerebral perfusion pressure
dc.subjectStroke
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleQuantitative EEG Correlates of Low Cerebral Perfusion in Severe Stroke
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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