New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry
dc.catalogador | jwg | |
dc.contributor.author | Vicuña, Lucas | |
dc.contributor.author | Barrientos, Esteban | |
dc.contributor.author | Norambuena, Tomás | |
dc.contributor.author | Alvares, Danilo | |
dc.contributor.author | Gana Ansaldo, Juan Cristóbal | |
dc.contributor.author | Leiva Yamaguchi, Valeria | |
dc.contributor.author | Meza, Cristian | |
dc.contributor.author | Lorenzoni Santos, José Guillermo | |
dc.contributor.author | Mericq, Verónica | |
dc.contributor.author | Pereira, Ana | |
dc.contributor.author | Eyheramendy, Susana | |
dc.date.accessioned | 2024-01-17T19:06:22Z | |
dc.date.available | 2024-01-17T19:06:22Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5 - 2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P = 9.8 x 10(-9)). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Age-AR was significantly lower (P = 0.004) by 1.94 years and BMI at AR was significantly higher (P = 0.04) by 1.2 kg/m(2), in Mapuche children compared with Europeans. | |
dc.fechaingreso.objetodigital | 2024-05-30 | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.1016/j.isci.2023.106091 | |
dc.identifier.eissn | 2589-0042 | |
dc.identifier.uri | https://doi.org/10.1016/j.isci.2023.106091 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/80552 | |
dc.identifier.wosid | WOS:000990651700001 | |
dc.information.autoruc | Escuela de Medicina; Gana Ansaldo Juan Cristobal; 0000-0002-0400-2164; 8726 | |
dc.information.autoruc | Escuela de Medicina; Lorenzoni Santos Jose Guillermo; ; 80739 | |
dc.issue.numero | 2 | |
dc.language.iso | en | |
dc.nota.acceso | Contenido completo | |
dc.publisher | CELL PRESS | |
dc.revista | ISCIENCE | |
dc.rights | acceso abierto | |
dc.subject | Genomics | |
dc.subject | Health sciences | |
dc.subject | Human genetics | |
dc.subject.ddc | 610 | |
dc.subject.dewey | Medicina y salud | es_ES |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry | |
dc.type | artículo | |
dc.volumen | 26 | |
sipa.codpersvinculados | 8726 | |
sipa.codpersvinculados | 80739 | |
sipa.trazabilidad | WOS;2023-07-06 | |
sipa.trazabilidad | ORCID;2024-01-08 |
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