11β-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activityActividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos

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dc.article.number106217
dc.contributor.authorFardella B C.
dc.contributor.authorMosso G L.
dc.contributor.authorCarvajal M C.
dc.contributor.authorCampino J C.
dc.contributor.authorRojas O A.
dc.contributor.authorGonzález P A.
dc.contributor.authorBarraza M A.
dc.contributor.authorMontero L J.
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:21Z
dc.date.available2024-08-15T08:00:21Z
dc.date.issued2002
dc.description.abstractBackground: Half of hypertensive patients with low plasma renin activity have a primary hyperaldosteronism. Among the remaining half, 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) deficiency plays an important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11βHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ng/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1±3.3 and 9.2±2.8 μg/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4±1.3 and 3.7±1.2 μg/dl, respectively). Four hypertensive subjects had an abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with low plasma renin activity and aldosterone had biochemical alterations suggestive of 11βHSD2 deficiency (Rev Méd Chile 2002; 130: 1201-8).
dc.description.funderANID through FONDECYT
dc.format.extent16 páginas
dc.fuente.origenScopus
dc.identifier.doi10.5194/cp-20-1579-2024
dc.identifier.eissn1814-9332
dc.identifier.issn00349887
dc.identifier.pubmedid12587501
dc.identifier.scopusidSCOPUS_ID:0036878417
dc.identifier.urihttps://doi.org/10.5194/cp-20-1579-2024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87464
dc.identifier.wosidWoS_ID: 001274878600001
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero7
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1208
dc.pagina.inicio1201
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaRevista Medica de Chile
dc.rightsregistro bibliográfico
dc.subject11β-Hydroxysteroid dehydrogenases
dc.subjectAldosterone
dc.subjectHypertension
dc.subjectRenin-angiotensin system
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.title11β-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activityActividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
dc.typeartículo
dc.volumen130
sipa.codpersvinculados88201
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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