Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico

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dc.catalogadoryvc
dc.contributor.authorTumani Karmy, María Fernanda
dc.contributor.authorTapia, Gladys
dc.contributor.authorAguirre, Carolina
dc.contributor.authorObregón, Ana María
dc.contributor.authorPettinelli, Paulina
dc.date.accessioned2024-10-23T16:47:26Z
dc.date.available2024-10-23T16:47:26Z
dc.date.issued2021
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes in the composition and function of the IM are associated with different diseases, including NAFLD. In this condition, IM could have a pathogenic role through different mechanisms such as energy salvaging from food, an inflammatory stimulus, a modulation of the innate immune system, regulation of bile acid turnover, alteration of choline metabolism and increasing endogenous ethanol levels. This review is an update on the role of the intestinal microbiota in NAFLD and the possible mechanisms involved.
dc.description.funderANID FONDECYT Iniciación No. 11150685
dc.description.funderANID Programa de Becas Magister Nacional Folio 22200024 2020
dc.fechaingreso.objetodigital2024-10-23
dc.format.extent9 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/s0034-98872021000400570
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.scopusidScopus_ID: 85113937523
dc.identifier.urihttps://www.scielo.cl/pdf/rmc/v149n4/0717-6163-rmc-149-04-0570.pdf
dc.identifier.urihttp://dx.doi.org/10.4067/s0034-98872021000400570
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88341
dc.information.autorucEscuela de Medicina; Tumani Karmy, María Fernanda; S/I; 231813
dc.language.isoes
dc.nota.accesocontenido completo
dc.pagina.final579
dc.pagina.inicio570
dc.publisherSociedad Médica de Santiago
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.subjectDysbiosis
dc.subjectGastrointestinal Microbiome
dc.subjectNon-alcoholic Fatty Liver Disease
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well being
dc.subject.odspa03 Salud y Bienestar
dc.titleRol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
dc.title.alternativeThe role of intestinal microbiota in the development of non-alcoholic fatty liver disease
dc.typeartículo
dc.volumen149
sipa.codpersvinculados231813
sipa.trazabilidadScopus;12-10-2021
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