Fast and accessible T2 mapping using off-resonance corrected DESPOT2 with application to 3D prostate

Simple item page
dc.contributor.authorCoronado, Ronal
dc.contributor.authorCastillo-Passi, Carlos
dc.contributor.authorBesa, Cecilia
dc.contributor.authorIrarrazaval, Pablo
dc.date.accessioned2025-01-20T16:18:19Z
dc.date.available2025-01-20T16:18:19Z
dc.date.issued2024
dc.description.abstractPurpose: Most T1 and T2 mapping take long acquisitions or needs specialized sequences not widely accessible on clinical scanners. An available solution is DESPOT1/T2 (Driven equilibrium single pulse observation of T1/T2). DESPOT1/T2 uses Spoiled gradient-echo (SPGR) and balanced Steady-State Free Precession (bSSFP) sequences, offering an accessible and reliable way for 3D accelerated T1/T2 mapping. However, bSSFP is prone to offresonance artifacts, limiting the application of DESPOT2 in regions with high susceptibility contrasts, like the prostate. Our proposal, DESPO+, employs the full bSSFP and SPGR models with a dictionary-based method to reconstruct 3D T1/T2 maps in the prostate region without off-resonance banding. Methods: DESPO+ modifies the bSSFP acquisition of the original variable flip angle DESPOT2. DESPO+ uses variable repetition and echo times, employing a dictionary-based method of the full bSSFP and SPGR models to reconstruct T1, T2, and Proton Density (PD) simultaneously. The proposed DESPO+ method underwent testing through simulations, T1/T2 phantoms, and on fourteen healthy subjects. Results: The results reveal a significant reduction in T2 map banding artifacts compared to the original DESPOT2 method. DESPO+ approach reduced T2 errors by up to seven times compared to DESPOT2 in simulations and phantom experiments. We also synthesized in-vivo T1-weighted/T2-weighted images from the acquired maps using a spin-echo model to verify the map's quality when lacking a reference. For in-vivo imaging, the synthesized images closely resemble those from the clinical MRI protocol, reducing scan time by around 50% compared to traditional spin-echo T1-weighted/T2-weighted acquisitions. Conclusion: DESPO+ provides an off-resonance insensitive and clinically available solution, enabling highresolution 3D T1/T2 mapping and synthesized T1-weighted/T2-weighted images for the entire prostate, all achieved within a short scan time of 3.6 min, similar to DESPOT1/T2.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.mri.2024.03.018
dc.identifier.eissn1873-5894
dc.identifier.issn0730-725X
dc.identifier.urihttps://doi.org/10.1016/j.mri.2024.03.018
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90641
dc.identifier.wosidWOS:001227038900001
dc.language.isoen
dc.pagina.final237
dc.pagina.inicio227
dc.revistaMagnetic resonance imaging
dc.rightsacceso restringido
dc.subjectOff -resonance effects
dc.subjectBalanced Steady State Free Precession (bSSFP)
dc.subjectDESPOT1/T2 (Driven equilibrium single pulse
dc.subjectobservation of T1/T2)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFast and accessible T2 mapping using off-resonance corrected DESPOT2 with application to 3D prostate
dc.typeartículo
dc.volumen109
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas