Determination of the rates of formation and hydrolysis of the Schiff bases formed by 5'-deoxypyridoxal and poly-L-lysine

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dc.contributor.authordelVado, MAG
dc.contributor.authorEchevarria, GR
dc.contributor.authorBlanco, JGS
dc.contributor.authorBlanco, FG
dc.date.accessioned2024-01-10T12:04:53Z
dc.date.available2024-01-10T12:04:53Z
dc.date.issued1997
dc.description.abstractThe kinetics of the reaction between 5'-deoxypyridoxal (DPL) and poly-L-lysine in aqueous solutions at a variable pH and a constant ionic strength of 0.1 M was studied spectrophotometrically. The rate constants of formation and hydrolysis of the resulting Schiff base and its stability constant at a variable pH were also determined. A comparison of the formation rate constant for the Schiff base with those for the models of pyridoxal 5'-phosphate (PLP) with poly-L-lysine and DPL with n-hexylamine revealed the effect of both the phosphate group of PLP and of the polypeptide chain on intramolecular catalysis in the dehydration of the intermediate carbinolamine formed. The effects of the polypeptide and the phosphate group on the hydrolysis of the Schiff base and hence on the base stability are also demonstrated.
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S1381-1169(96)00133-1
dc.identifier.issn1381-1169
dc.identifier.urihttps://doi.org/10.1016/S1381-1169(96)00133-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75903
dc.identifier.wosidWOS:A1997WT81900004
dc.information.autorucQuímica;Santos JG;S/I;98813
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final26
dc.pagina.inicio21
dc.publisherELSEVIER SCIENCE BV
dc.revistaJOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
dc.rightsacceso restringido
dc.subjectSchiff base
dc.subject5'-deoxypyridoxal
dc.subjectpoly-L-lysine
dc.subjecthydrolysis
dc.subjectPYRIDOXAL 5'-PHOSPHATE
dc.subjectNORMAL-HEXYLAMINE
dc.subjectNONAQUEOUS MEDIA
dc.subjectN-HEXYLAMINE
dc.subjectPOLYPEPTIDES
dc.subjectCATALYSIS
dc.subjectSTABILITY
dc.subjectPOLARITY
dc.subject.ods12 Responsible Consumption and Production
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa12 Producción y consumo responsable
dc.subject.odspa03 Salud y bienestar
dc.titleDetermination of the rates of formation and hydrolysis of the Schiff bases formed by 5'-deoxypyridoxal and poly-L-lysine
dc.typeartículo
dc.volumen118
sipa.codpersvinculados98813
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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