C-reactive protein and atrial fibrillation: "Evidence for the presence of inflammation in the perpetuation of the arrhythmia"

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dc.contributor.authorAcevedo, M
dc.contributor.authorCorbalan, R
dc.contributor.authorBraun, S
dc.contributor.authorPereira, J
dc.contributor.authorNavarrete, C
dc.contributor.authorGonzalez, I
dc.date.accessioned2024-01-10T12:04:46Z
dc.date.available2024-01-10T12:04:46Z
dc.date.issued2006
dc.description.abstractBackground: Atrial fibrillation (AF) is associated to a high risk of systemic embolism. The mechanisms that contribute to thrombogenesis in these patients are still poorly understood. Systemic and/or local inflammation could be involved in the process of thrombogenesis and contribute to the perpetuation of the arrhythmia. The purpose of the study was to evaluate the role of inflammation and its relation to thrombogenesis and cardiac rhythm in AF.
dc.description.abstractMethods: We prospectively studied 130 patients with newly diagnosed non-valvular AF in absence of antithrombotic therapy. Determinations of C-reactive protein (CRP) and thrombin-antithrombin complex (TAT) plasma levels, along with a transesophageal echocardiogram were performed in all the patients at admission.
dc.description.abstractResults: Mean age of the group was 67 14 years. CRP levels were significantly elevated in AF patients versus controls (matched by age, gender and cardiovascular risk factors) (1.0 +/- 1.8 versus 0.3 +/- 0.4 mg/dl, respectively, p < 0.01). Baseline TAT levels were also significantly elevated in AF patients but no correlation was found between CRP and TAT. At 1-year of follow-up, mean CRY levels were still elevated in patients that remained in AF compared to those who converted to sinus rhythm (1.2 +/- 1.8 compared to 0.5 +/- 1.5 mg/dl, p = 0.03). CRP was the only biochemical predictor of sinus rhythm maintenance at I-year follow-up independently of clinical (including adjustment for risk factors and antiarrhythmic drugs), biochemical and echo parameters.
dc.description.abstractConclusions: There is evidence for the presence of inflammation in patients with non-valvular AF, which is not related to activation of the coagulation cascade. The persistence of inflammation is associated with chronic AF at I-year follow up. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital25-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijcard.2005.05.017
dc.identifier.issn0167-5273
dc.identifier.pubmedidMEDLINE:15985301
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2005.05.017
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75875
dc.identifier.wosidWOS:000236475200006
dc.information.autorucMedicina;Acevedo M;S/I;81173
dc.information.autorucMedicina;Corbalán R;S/I;98700
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final331
dc.pagina.inicio326
dc.publisherELSEVIER IRELAND LTD
dc.revistaINTERNATIONAL JOURNAL OF CARDIOLOGY
dc.rightsacceso restringido
dc.subjectatrial fibrillation
dc.subjectC-reactive protein
dc.subjectinflammation
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectRISK-FACTOR
dc.subjectMECHANISMS
dc.subjectATHEROSCLEROSIS
dc.subjectTHROMBOGENESIS
dc.subjectINTERLEUKIN-6
dc.subjectACTIVATION
dc.subjectEXPRESSION
dc.subjectDECREASES
dc.subjectMARKERS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleC-reactive protein and atrial fibrillation: "Evidence for the presence of inflammation in the perpetuation of the arrhythmia"
dc.typeartículo
dc.volumen108
sipa.codpersvinculados81173
sipa.codpersvinculados98700
sipa.codpersvinculados99371
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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