Respiratory responses to pH in the absence of pontine and dorsal medullary areas in the newborn mouse in vitro

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dc.contributor.authorInfante, CD
dc.contributor.authorvon Bernhardi, R
dc.contributor.authorRovegno, M
dc.contributor.authorLlona, I
dc.contributor.authorEugenin, JL
dc.date.accessioned2024-01-10T12:08:13Z
dc.date.available2024-01-10T12:08:13Z
dc.date.issued2003
dc.description.abstractThe contribution of pons and dorsal medulla in establishing the pattern of fictive respiration and in mediating the respiratory response to acidification was studied using the isolated brainstem-spinal cord preparation from neonatal mouse. About 40% of ponto-medullary preparations (retaining pons) showed spontaneous, but irregular respiratory-like rhythm. In the other 60%, the elimination of the pons often was followed by the initiation of a respiratory-like rhythm. Medullary preparations, derived from either inactive or rhythmic ponto-medullary preparations, showed a regular respiratory-like rhythm, which was also of a higher frequency and a bigger amplitude than that observed in ponto-medullary preparations. In contrast, ventral medullary preparations, derived from medullary preparations by eliminating the dorsal medulla, showed an irregular rhythm with a reduced amplitude of the integrated inspiratory burst. In ponto-medullary and ventral medullary preparations, acidification of the superfusion medium increased the respiratory frequency, while in medullary preparations, it increased the frequency and reduced the amplitude of the inspiratory burst. Our results suggest that pontine structures influence negatively the rate and depth of the respiratory-like rhythm, while dorsal medullary structures influence positively the depth of the rhythm. They also suggest that the pattern of response to pH supported by the ventral medulla is modified by the input provided from pons and dorsal medulla. (C) 2003 Elsevier B.V. All rights reserved.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0006-8993(03)03155-X
dc.identifier.eissn1872-6240
dc.identifier.issn0006-8993
dc.identifier.pubmedidMEDLINE:12932854
dc.identifier.urihttps://doi.org/10.1016/S0006-8993(03)03155-X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76370
dc.identifier.wosidWOS:000185316200021
dc.information.autorucMedicina;Von Bernhardi R;S/I;62523
dc.issue.numero1-2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final205
dc.pagina.inicio198
dc.publisherELSEVIER
dc.revistaBRAIN RESEARCH
dc.rightsacceso restringido
dc.subjectcentral chemoreception
dc.subjectlocus coeruleus
dc.subjectnucleus tractus solitarius
dc.subjectbrainstem
dc.subjectSTEM-SPINAL-CORD
dc.subjectRAT INCREASES VENTILATION
dc.subjectISOLATED BRAIN-STEM
dc.subjectCENTRAL CHEMOSENSITIVITY
dc.subjectRHYTHM GENERATION
dc.subjectCO2 DIALYSIS
dc.subjectISOLATED CNS
dc.subjectNEURONS
dc.subjectSLEEP
dc.subjectCHEMORECEPTORS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRespiratory responses to pH in the absence of pontine and dorsal medullary areas in the newborn mouse in vitro
dc.typeartículo
dc.volumen984
sipa.codpersvinculados62523
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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