Administration of growth hormone to patients with advanced cardiac heart failure: effects upon left ventricular function, exercise capacity, and neurohormonal status

Simple item page
dc.contributor.authorAcevedo, M
dc.contributor.authorCorbalan, R
dc.contributor.authorChamorro, G
dc.contributor.authorJalil, J
dc.contributor.authorNazzal, C
dc.contributor.authorCampusano, C
dc.contributor.authorCastro, P
dc.date.accessioned2024-01-10T12:04:08Z
dc.date.available2024-01-10T12:04:08Z
dc.date.issued2003
dc.description.abstractExperimental and clinical studies have shown that the administration of recombinant human growth hormone can improve deteriorated left ventricular function and hemodynamics in patients with heart failure. Herein, we compared the effects of growth hormone versus placebo upon resting left ventricular ejection fraction, exercise capacity and neurohormonal status in patients with advanced heart failure. Nineteen patients with advanced cardiac heart failure (ejection fraction <30%) were studied at baseline and after 8 weeks of treatment with growth hormone (0.03 U/kg per day) or placebo. Primary end points were resting left ventricular ejection fraction, peak oxygen consumption and neurohormonal status, including plasma norepinephrine levels and insulin like growth factor-1 and its binding protein-3. Results are presented as median and interquartile ranges. Patients receiving growth hormone had a significant increase in insulin growth factor-1 plasma levels (median difference growth hormone=83 ng/ml [57-170] versus placebo=-6 ng/ml [-23-6], P<0.05) and its binding protein-3. However, no significant increase in left ventricular ejection fraction after growth hormone treatment (ejection fraction pre=16% [13-18] and post=17% [14-27]) was noticed when compared to placebo (ejection fraction pre=20% [15-24] and post=20% [15-26]). Also, no significant effect of growth hormone treatment was seen on peak oxygen consumption or norepinephrine plasma levels. Although the administration of growth hormone to patients with advanced cardiac heart failure was associated with a significant increase in insulin growth factor-1, there were no significant changes in ejection fraction, exercise capacity and/or neurohormonal status. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0167-5273(02)00249-8
dc.identifier.eissn1874-1754
dc.identifier.issn0167-5273
dc.identifier.pubmedidMEDLINE:12559539
dc.identifier.urihttps://doi.org/10.1016/S0167-5273(02)00249-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75695
dc.identifier.wosidWOS:000181168800013
dc.information.autorucMedicina;Acevedo M;S/I;81173
dc.information.autorucMedicina;Castro P;S/I;100212
dc.information.autorucMedicina;Corbalán R;S/I;98700
dc.information.autorucMedicina;Jalil J;S/I;99946
dc.issue.numero2-3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final191
dc.pagina.inicio185
dc.publisherELSEVIER IRELAND LTD
dc.revistaINTERNATIONAL JOURNAL OF CARDIOLOGY
dc.rightsacceso restringido
dc.subjectheart failure
dc.subjectgrowth hormone
dc.subjectinsulin like growth factor-1
dc.subjectcardiac function
dc.subjectneurohormonal status
dc.subjectDILATED CARDIOMYOPATHY
dc.subjectFACTOR-I
dc.subjectCACHEXIA
dc.subjectTHERAPY
dc.subjectADULTS
dc.subjectTRIAL
dc.subjectRATS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdministration of growth hormone to patients with advanced cardiac heart failure: effects upon left ventricular function, exercise capacity, and neurohormonal status
dc.typeartículo
dc.volumen87
sipa.codpersvinculados81173
sipa.codpersvinculados100212
sipa.codpersvinculados98700
sipa.codpersvinculados99946
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-04-16. Administration of growth hormone to patients with advanced cardiac heart failure.pdf
Size:
3.11 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas