Tissue kallikrein and bradykinin B2 receptor in human uterus in luteal phase and in early and late gestation

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dc.contributor.authorValdés, G
dc.contributor.authorGermain, AM
dc.contributor.authorCorthorn, J
dc.contributor.authorChacón, C
dc.contributor.authorFigueroa, CD
dc.contributor.authorMüller-Esterl, W
dc.date.accessioned2025-01-21T01:30:37Z
dc.date.available2025-01-21T01:30:37Z
dc.date.issued2001
dc.description.abstractThis study was addressed to evaluate the temporo-spatial pattern of key components of the kallikrein-kinin system in human uterus in luteal phase (n = 7), early pregnancy (isolated spontaneous abortions, n = 11; ectopic pregnancies, n = 9), idiopathic preterm deliveries (n = 5), and term gestations (n = 12). Tissue kallikrein mRNA and protein and the type 2 bradykinin receptor (B2R) protein were expressed in luminal and glandular epithelium and in endothelial cells of stromal and myometrial blood vessels, while tissue kallikrein mRNA and B2R, but not tissue kallikrein protein, were observed in decidual cells and in arteriolar and myometrial muscle. A greater signal intensity for tissue kallikrein mRNA and protein and of B2R protein was observed in the early pregnancy samples. The sites and variations of the tissue kallikrein mRNA and protein and of the B2R protein in the human uterus and in fallopian tubes during the luteal phase and in pregnancy coincide with those described for other vasoactive effectors such as nitric oxide, prostacyclins, growth factors, and renin. The uterine localization of the main enzyme and receptor of the tissue kallikrein-kinin system in key sites for embryo attachment, implantation, placentation, maintenance of placental blood flow, and parturition supports the notion that the kallikrein-kinin system participates in these processes, probably through vasodilation, increased vasopermeability, enhanced matrix degradation, stimulation of cell proliferation, and myometrial contractility.
dc.fuente.origenWOS
dc.identifier.eissn1559-0100
dc.identifier.issn1355-008X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96831
dc.identifier.wosidWOS:000174537500008
dc.issue.numero3
dc.language.isoen
dc.pagina.final215
dc.pagina.inicio207
dc.revistaEndocrine
dc.rightsacceso restringido
dc.subjecttissue kallikrein
dc.subjecttype 2 bradykinin receptor
dc.subjecthuman uterus
dc.subjectpregnancy
dc.subjectspontaneous abortions
dc.subjectectopic pregnancy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTissue kallikrein and bradykinin B2 receptor in human uterus in luteal phase and in early and late gestation
dc.typeartículo
dc.volumen16
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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