The role of myeloid-derived suppressor cells in chronic infectious diseases and the current methodology available for their study

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dc.catalogadordfo
dc.contributor.authorPeñaloza Cerda, Hernán F.
dc.contributor.authorÁlvarez Espejo, Diana Claudia Marcela
dc.contributor.authorMuñoz Durango, Natalia
dc.contributor.authorSchultz Lombardic, Bárbara M.
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorBueno Ramírez, Susan
dc.date.accessioned2024-01-31T12:39:22Z
dc.date.available2024-01-31T12:39:22Z
dc.date.issued2019
dc.description.abstractAn effective pathogen has the ability to evade the immune response. The strategies used to achieve this may be based on the direct action of virulence factors or on the induction of host factors. Myeloid-derived suppressor cells (MDSCs) are immune cells with an incredible ability to suppress the inflammatory response, which makes them excellent targets to be exploited by pathogenic bacteria, viruses, or parasites. In this review, we describe the origin and suppressive mechanisms of MDSCs, as well as their role in chronic bacterial, viral, and parasitic infections, where their expansion seems to be essential in the chronicity of the disease. We also analyze the disadvantages of current MDSC depletion strategies and the different in vitro generation methods, which can be useful tools for the deeper study of these cells in the context of microbial infections.
dc.fechaingreso.objetodigital2025-01-03
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1002/JLB.MR0618-233R
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81091
dc.identifier.wosidWOS:000465598200004
dc.information.autorucFacultad de Ciencias Biológicas; Peñaloza Cerda, Hernán F.; S/I; 186994
dc.information.autorucFacultad de Ciencias Biológicas; Álvarez Espejo, Diana Claudia Marcela; S/I; 250646
dc.information.autorucFacultad de Ciencias Biológicas; Muñoz Durango, Natalia; S/I; 218064
dc.information.autorucFacultad de Ciencias Biológicas; Schultz Lombardic, Bárbara M.; 0000-0002-6201-6978; 186964
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final872
dc.pagina.inicio857
dc.revistaJournal of Leukocyte Biology
dc.rightsacceso restringido
dc.subjectMDSC depletion
dc.subjectMDSCs in vitro generation
dc.subjectInfectious diseases
dc.subjectMyeloid-derived suppressor cells
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe role of myeloid-derived suppressor cells in chronic infectious diseases and the current methodology available for their study
dc.typeartículo
dc.volumen105
sipa.codpersvinculados186994
sipa.codpersvinculados250646
sipa.codpersvinculados218064
sipa.codpersvinculados186964
sipa.codpersvinculados90610
sipa.codpersvinculados113541
sipa.trazabilidadHistorial Académico;09-07-2021
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