Clinic and epidemiologic description of Clostridium difficile infection in a pediatric population

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dc.contributor.authorMaccioni, Andrea
dc.contributor.authorCerda, Jaime
dc.contributor.authorTerrazas, Claudia
dc.contributor.authorAbarca, Katia
dc.date.accessioned2024-01-10T13:11:48Z
dc.date.available2024-01-10T13:11:48Z
dc.date.issued2015
dc.description.abstractBackground: Clostridium difficile (CD)-associated disease (CDAD) and the role of the hypervirulent strain NAP1 have not been well characterized in Pediatrics. Aims: To describe clinical features of CDAD, and to estimate NAP1 frequency and association with disease severity in Pediatrics. Methods: Descriptive, transversal surveillance of diarrheal episodes in Chilean children, hospitalized between February 2012 and December 2013, positive for CD by molecular diagnosis. Results: A total of 66 episodes of diarrhea with identification of CD occurred thougout the study period in children between 1 month and 19 years of age of which 39% were younger than one year old. CD acquisition was predominantly nosocomial and the most common risk factors were: presence of comorbidities (98.6%), use of antibiotics (93.9%), proton pump inhibitors (84.8%), invasive mechanic ventilation (54.5%), feeding tube (48.5%) and immunosuppression (40.9%). Clinical course was mostly mild, but 12 cases presented an unfavorable course, of which 3/26 occurred in children less than one year. Only one case was positive for NAP1 and had a mild course. Conclusion: Diarrhea with identification of CD was present throughout all pediatric ages, including children less than one year old. Analytical and longitudinal studies are required to better characterize the pathogenic role of CD in this age group. CDAD occurred mostly in patients with risk factors, and the clinical course was predominantly mild.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:26633108
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78099
dc.identifier.wosidWOS:000364732900005
dc.information.autorucMedicina;Abarca K;S/I;70281
dc.information.autorucMedicina;Cerda J;S/I;3935
dc.information.autorucMedicina;Maccioni A ;S/I;218717
dc.information.autorucMedicina;Terrazas C ;S/I;171169
dc.issue.numero5
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final529
dc.pagina.inicio523
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsregistro bibliográfico
dc.subjectClostridium difficile
dc.subjectClostridium difficile-associated infection
dc.subjectPediatrics
dc.subjectBI/NAP1/027
dc.subjectRISK-FACTORS
dc.subjectACID SUPPRESSION
dc.subjectCHILDREN
dc.subjectOUTCOMES
dc.subjectSOCIETY
dc.subjectDISEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinic and epidemiologic description of Clostridium difficile infection in a pediatric population
dc.typeartículo
dc.volumen32
sipa.codpersvinculados70281
sipa.codpersvinculados3935
sipa.codpersvinculados218717
sipa.codpersvinculados171169
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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