Population pharmacokinetics of amikacin in suspected cases of neonatal sepsis

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dc.catalogadorgrr
dc.contributor.authorSeverino Cuevas, Nicolás Felipe
dc.contributor.authorUrzúa Baquedano, Maria Soledad
dc.contributor.authorIbacache Figueroa, Mauricio Enrique
dc.contributor.authorPaulos Arenas, Claudio
dc.contributor.authorCortinez Fernandez, Luis Ignacio
dc.contributor.authorToso Milos, Alberto Antonio
dc.contributor.authorLeguizamon Marino, Liliana Marcela
dc.contributor.authorInojosa Mackenzie, Fernanda
dc.contributor.authorMaccioni Romero, Andrea Ana
dc.contributor.authorMeza Cañas, Sebastián Jaime
dc.contributor.authorGarcia, Andres
dc.contributor.authorRamirez, Marcelo
dc.contributor.authorVon Mentlen Gutierrez, Catalina Paz
dc.contributor.authorCeballos Jorquera Javiera Nicol
dc.contributor.authorParedes Galvez, Noemi Saray
dc.date.accessioned2024-01-17T14:24:00Z
dc.date.available2024-01-17T14:24:00Z
dc.date.issued2023
dc.description.abstractAims:This study aimed to characterize the population pharmacokinetic parameters of intravenously administered amikacin in newborns and assess the effect of sepsis in amikacin exposure. Methods: Newborns aged >= 3 days who received at least 1 dose of amikacin during their hospitalization period were eligible for the study. Amikacin was administered intravenously during a 60-min infusion period. Three venous blood samples were taken from each patient during the first 48 h. Population pharmacokinetic parameter estimates were obtained using a population approach with the programme NONMEM. ResultsData from 329 drug assay samples were obtained from 116 newborn patients (postmenstrual age [PMA] 38.3, range 32-42.4 weeks; weight 2.8, range 1.6-3.8 kg). Measured amikacin concentrations ranged from 0.8 to 56.4 mg/L. A 2-compartment model with linear elimination produced a good fit of the data. Estimated parameters for a typical subject (2.8 kg, 38.3 weeks) were clearance (Cl = 0.16 L/h), intercompartmental clearance (Q = 0.15 L/h), volume of distribution of the central compartment (Vc = 0.98 L) and peripheral volume of distribution (Vp = 1.23 L). Total bodyweight, PMA and the presence of sepsis positively influenced Cl. Plasma creatinine concentration and circulatory instability (shock) negatively influenced Cl. ConclusionOur main results confirm previous findings showing that weight, PMA and renal function are relevant factors influencing newborn amikacin pharmacokinetics. In addition, current results showed that pathophysiological states of critically ill neonates, such as sepsis and shock, were associated with opposite effects in amikacin clearance and should be considered in dose adjustments.
dc.fechaingreso.objetodigital2024-01-17
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1111/bcp.15697
dc.identifier.eissn1365-2125
dc.identifier.issn0306-5251
dc.identifier.pubmedid36811146
dc.identifier.urihttps://doi.org/10.1111/bcp.15697
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80546
dc.identifier.wosidWOS:000949405300001
dc.information.autorucEscuela de Medicina; Severino Cuevas, Nicolás Felipe; 0000-0002-9950-3606; 149398
dc.information.autorucEscuela de Medicina; Urzuúa Baquedano, Maria Soledad; 0000-0002-6401-4845; 135691
dc.information.autorucEscuela de Medicina; Ibacache Figueroa, Mauricio Enrique; S/I; 817
dc.information.autorucEscuela de Química; Paulos Arenas, Claudio ; 0000-0002-9857-0567; 52691
dc.information.autorucEscuela de Medicina; Cortinez Fernandez, Luis Ignacio; 0000-0001-8544-8768; 79356
dc.information.autorucEscuela de Medicina; Toso Milos, Alberto Antonio; 0000-0002-3809-2567; 238020
dc.information.autorucEscuela de Medicina; Leguizamon Marino, Liliana Marcela; S/I; 199887
dc.information.autorucEscuela de Medicina; Inojosa Mackenzie, Fernanda; 0009-0006-0267-3294; 1013936
dc.information.autorucEscuela de Medicina; Maccioni Romero, Andrea Ana; 0009-0009-9810-8426; 218717
dc.information.autorucEscuela de Química; Meza Cañas, Sebastián Jaime; S/I; 247089
dc.information.autorucEscuela de Química; Von Mentlen Gutierrez, Catalina Paz; S/I; 233911
dc.information.autorucEscuela de Química; Ceballos Jorquera Javiera Nicol; S/I; 247105
dc.information.autorucEscuela de Química; Paredes Galvez, Noemi Saray ; S/I; 1027546
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final2262
dc.pagina.inicio2254
dc.publisherWiley
dc.revistaBritish Journal of Clinical Pharmacology
dc.rightsacceso abierto
dc.subjectAntibiotics
dc.subjectInfectious diseases
dc.subjectNeonatology
dc.subjectPaediatrics
dc.subjectPharmacometrics
dc.subjectSepsis
dc.subject610
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePopulation pharmacokinetics of amikacin in suspected cases of neonatal sepsis
dc.typeartículo
dc.volumen89
sipa.codpersvinculados149398
sipa.codpersvinculados135691
sipa.codpersvinculados817
sipa.codpersvinculados52691
sipa.codpersvinculados79356
sipa.codpersvinculados238020
sipa.codpersvinculados199887
sipa.codpersvinculados1013936
sipa.codpersvinculados218717
sipa.codpersvinculados247089
sipa.codpersvinculados233911
sipa.codpersvinculados247105
sipa.codpersvinculados1027546
sipa.trazabilidadORCID;2024-01-15
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