Radiographic Severity of Rheumatoid Arthritis in African Americans: Results From a Multicenter Observational Study

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dc.contributor.authorBridges, S. Louis, Jr.
dc.contributor.authorCausey, Zenoria L.
dc.contributor.authorBurgos, Paula I.
dc.contributor.authorHuynh, B. Quynh N.
dc.contributor.authorHughes, Laura B.
dc.contributor.authorDanila, Maria I.
dc.contributor.authorvan Everdingen, Amalia
dc.contributor.authorLedbetter, Stephanie
dc.contributor.authorConn, Doyt L.
dc.contributor.authorTamhane, Ashutosh
dc.contributor.authorWestfall, Andrew O.
dc.contributor.authorJonas, Beth L.
dc.contributor.authorCallahan, Leigh F.
dc.contributor.authorSmith, Edwin A.
dc.contributor.authorBrasington, Richard
dc.contributor.authorMoreland, Larry W.
dc.contributor.authorAlarcon, Graciela S.
dc.contributor.authorvan der Heijde, Desiree M.
dc.date.accessioned2024-01-10T12:07:56Z
dc.date.available2024-01-10T12:07:56Z
dc.date.issued2010
dc.description.abstractObjective. To describe radiographic changes in African Americans with rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluations of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry, a multicenter observational study.
dc.description.abstractMethods. Self-declared African American patients were enrolled in CLEAR I, a longitudinal cohort of early RA (disease duration of <2 years) from 2000 to 2005, or in CLEAR II, a cross-sectional cohort (any disease duration) from 2006 to the present. Demographic and clinical data were obtained, and sets of hand/wrist and foot radiographs were scored using the modified Sharp/van der Heijde scoring system.
dc.description.abstractResults. A total of 357 and 418 patients were enrolled in CLEAR I and CLEAR II, respectively. We report here an interim analysis of radiographic severity in these patients. For the CLEAR I cohort, 294 patients had a mean radiographic score of 2.89 at the baseline visit; 32.0% showed either erosions (25.9%) or joint space narrowing (JSN; 19.4%). At the 36-month visit, the mean score was 5.65; 44.2% had erosions, 41.5% had JSN, and 54.4% had either. Among those patients without radiographic damage at baseline, 18.9% had progressed at the 36-month visit, compared with 57.1% of those with baseline damage (P < 0.0001). For the CLEAR II cohort, of 167 patients with RA of any duration, 65.3% exhibited joint erosions, 65.3% exhibited JSN, and 74.8% exhibited either. The mean radiographic score was 33.42.
dc.description.abstractConclusion. To our knowledge, this is the largest radiographic study of African American RA patients. Damage occurs early in the disease and is associated with radiographic progression at 3 years of disease duration. The CLEAR Registry will provide a valuable resource for future analyses of genetic, clinical, and environmental factors associated with radiographic severity of RA in African Americans.
dc.description.funderNIH
dc.description.funderGeneral Clinical Research Centers
dc.description.funderEmory University/Grady Hospital
dc.description.funderUniversity of North Carolina
dc.description.funderMedical University of South Carolina
dc.description.funderPrograma de Postgrado Beca Chile
dc.description.funderNATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
dc.description.funderNATIONAL CENTER FOR RESEARCH RESOURCES
dc.description.funderNATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
dc.fechaingreso.objetodigital02-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/acr.20040
dc.identifier.issn2151-464X
dc.identifier.pubmedidMEDLINE:20461784
dc.identifier.urihttps://doi.org/10.1002/acr.20040
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76339
dc.identifier.wosidWOS:000280979600007
dc.information.autorucMedicina;Burgos PI;S/I;93093
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final631
dc.pagina.inicio624
dc.publisherWILEY-LISS
dc.revistaARTHRITIS CARE & RESEARCH
dc.rightsacceso restringido
dc.subjectPROSPECTIVE FOLLOW-UP
dc.subjectRADIOLOGICAL PROGRESSION
dc.subjectJOINT DESTRUCTION
dc.subjectNEGRO POPULATION
dc.subjectDISEASE-ACTIVITY
dc.subjectCLINICAL-TRIALS
dc.subjectMOTION SCALE
dc.subjectDAMAGE
dc.subjectBLACKS
dc.subjectASSOCIATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRadiographic Severity of Rheumatoid Arthritis in African Americans: Results From a Multicenter Observational Study
dc.typeartículo
dc.volumen62
sipa.codpersvinculados93093
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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