Oscillatory pattern of glycemic control in patients with diabetes mellitus

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dc.contributor.authorVasquez-Munoz, Manuel
dc.contributor.authorArce-Alvarez, Alexis
dc.contributor.authorvon Igel, Magdalena
dc.contributor.authorVeliz, Carlos
dc.contributor.authorRuiz-Esquide, Gonzalo
dc.contributor.authorRamirez-Campillo, Rodrigo
dc.contributor.authorAlvarez, Cristian
dc.contributor.authorRamirez-Velez, Robinson
dc.contributor.authorCrespo, Fernando A.
dc.contributor.authorIzquierdo, Mikel
dc.contributor.authorDel Rio, Rodrigo
dc.contributor.authorAndrade, David C.
dc.date.accessioned2025-01-20T23:51:28Z
dc.date.available2025-01-20T23:51:28Z
dc.date.issued2021
dc.description.abstractDaily glucose variability is higher in diabetic mellitus (DM) patients which has been related to the severity of the disease. However, it is unclear whether glycemic variability displays a specific pattern oscillation or if it is completely random. Thus, to determine glycemic variability pattern, we measured and analyzed continuous glucose monitoring (CGM) data, in control subjects and patients with DM type-1 (T1D). CGM data was assessed for 6 days (day: 08:00-20:00-h; and night: 20:00-08:00-h). Participants (n =172; age =18-80 years) were assigned to T1D (n =144, females = 65) and Control (i.e., healthy; n = 28, females = 22) groups. Anthropometry, pharmacologic treatments, glycosylated hemoglobin (HbA1c) and years of evolution were determined. T1D females displayed a higher glycemia at 10:00-14:00-h vs. T1D males and Control females. DM patients displays mainly stationary oscillations (deterministic), with circadian rhythm characteristics. The glycemia oscillated between 2 and 6 days. The predictive model of glycemia showed that it is possible to predict hyper and hypoglycemia (R-2 =0.94 and 0.98, respectively) in DM patients independent of their etiology. Our data showed that glycemic variability had a specific oscillation pattern with circadian characteristics, with episodes of hypoglycemia and hyperglycemia at day phases, which could help therapeutic action for this population.
dc.description.funder"Vicerrectoria de Investigacion" from Universidad Mayor
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-021-84822-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-021-84822-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94819
dc.identifier.wosidWOS:000629623300063
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOscillatory pattern of glycemic control in patients with diabetes mellitus
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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