Plasticity in primary somatosensory cortex resulting from environmentally enriched stimulation and sensory discrimination training

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dc.contributor.authorGuic, Eliana
dc.contributor.authorCarrasco, Ximena
dc.contributor.authorRodriguez, Eugenio
dc.contributor.authorRobles, Ignacio
dc.contributor.authorMerzenich, Michael M.
dc.date.accessioned2025-01-21T01:05:14Z
dc.date.available2025-01-21T01:05:14Z
dc.date.issued2008
dc.description.abstractWe studied primary-somatosensory cortical plasticity due to selective stimulation of the sensory periphery by two procedures of active exploration in adult rats. Subjects, left with only three adjacent whiskers, were trained in a roughness discrimination task or maintained in a tactile enriched environment. Either training or enrichment produced 3-fold increases in the barrel cortex areas of behaviorally-engaged whisker representations, in their zones of overlap, While the overall areas of representation expanded dramatically, the domains of exclusive principal whisker responses were virtually identical in enriched vs normal rats and were significantly smaller than either group in roughness discrimination-trained rats. When animals were trained or exposed to enriched environments with the three whiskers arrayed in an arc or row, very equivalent overlaps in representations were recorded across their greatly-enlarged whisker representation zones. This equivalence in distortion in these behavioral preparations is in contradistinction to the normal rat, where overlap is strongly biased only along rows, probably reflecting the establishment of different relations with the neighboring cortical columns. Overall, plasticity phenomena are argued to be consistent with the predictions of competitive Hebbian network plasticity.
dc.fuente.origenWOS
dc.identifier.issn0716-9760
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95869
dc.identifier.wosidWOS:000264574400008
dc.issue.numero4
dc.language.isoen
dc.pagina.final437
dc.pagina.inicio425
dc.revistaBiological research
dc.rightsacceso restringido
dc.subjectcortical plasticity
dc.subjectroughness discrimination
dc.subjectenvironmental enrichment
dc.subjectbarrel cortex
dc.subjectactive exploration
dc.titlePlasticity in primary somatosensory cortex resulting from environmentally enriched stimulation and sensory discrimination training
dc.typeartículo
dc.volumen41
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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