Physiological and clinical effects of diurnal noninvasive ventilation in hypercapnic COPD

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dc.contributor.authorDiaz, O
dc.contributor.authorBegin, P
dc.contributor.authorAndresen, M
dc.contributor.authorPrieto, ME
dc.contributor.authorCastillo, C
dc.contributor.authorJorquera, J
dc.contributor.authorLisboa, C
dc.date.accessioned2024-01-10T13:16:16Z
dc.date.available2024-01-10T13:16:16Z
dc.date.issued2005
dc.description.abstractTo assess the clinical impact of noninvasive mechanical ventilation (NIMV) on stable hypercapnic chronic obstructive pulmonary disease, changes in exercise capacity, dyspnoea and simple physiological parameters were evaluated. The time course of these effects during treatment and recovery was also assessed.
dc.description.abstractPatients were randomly allocated to NIMV (n=27) or sham-NIMV (n=15), applied 3 h.day(-1), 5 days a week, for 3 weeks. A 6-min walking distance (6MWD), arterial blood gases, spirometry, pattern of breathing, mouth occlusion pressure (P0.1), and respiratory system impedance (P0.1/tidal volume (VT)/inspiratory time (tI)) were measured weekly during treatment and 2 weekly during follow-up. Transition dyspnoea index (TDI) was also measured.
dc.description.abstractDuring NIMV, carbon dioxide arterial tension decreased progressively, concomitantly with a slow deep pattern of breathing, a proportional increase in the forced expiratory volume in one second (FEV1), the forced vital capacity and significant reductions of P0.1 and P0.1/VT/tI. The 6MWD improved by a mean of 76 m after NIMV, and by 73 m and 61 m 1 and 2 weeks, respectively, after treatment. Dyspnoea improved with a mean TDI of three points. Changes in 6MWD were highly related to TDI and to a lesser extent to changes in FEV1 (r=0.60).
dc.description.abstractThe current authors conclude that noninvasive mechanical ventilation has significant and sustained clinical impact in stable hypercapnic chronic obstructive pulmonary disease.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1183/09031936.05.00033905
dc.identifier.eissn1399-3003
dc.identifier.issn0903-1936
dc.identifier.pubmedidMEDLINE:16319330
dc.identifier.urihttps://doi.org/10.1183/09031936.05.00033905
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78572
dc.identifier.wosidWOS:000234203100009
dc.information.autorucMedicina;Andresen M;S/I;54274
dc.information.autorucMedicina;Díaz O;S/I;78564
dc.information.autorucMedicina;Lisboa C;S/I;98551
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1023
dc.pagina.inicio1016
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.revistaEUROPEAN RESPIRATORY JOURNAL
dc.rightsacceso restringido
dc.subjectchronic obstructive pulmonary disease
dc.subjectdyspnoea
dc.subjectexercise capacity
dc.subjecthypercapnia
dc.subjectnoninvasive ventilation
dc.subjectPOSITIVE-PRESSURE VENTILATION
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectLUNG HYPERINFLATION
dc.subjectSUPPORT VENTILATION
dc.subjectEXERCISE
dc.subjectDYSPNEA
dc.subjectEFFICACY
dc.subjectFAILURE
dc.subjectINDEX
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePhysiological and clinical effects of diurnal noninvasive ventilation in hypercapnic COPD
dc.typeartículo
dc.volumen26
sipa.codpersvinculados54274
sipa.codpersvinculados78564
sipa.codpersvinculados98551
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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