Syndecan-4 inhibits Wnt/β-catenin signaling through regulation of low-density-lipoprotein receptor-related protein (LRP6) and R-spondin 3
| dc.contributor.author | Astudillo, Pablo | |
| dc.contributor.author | Carrasco, Hector | |
| dc.contributor.author | Larrain, Juan | |
| dc.date.accessioned | 2025-01-23T21:48:09Z | |
| dc.date.available | 2025-01-23T21:48:09Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Regulation of Wnt signaling is crucial for embryonic development and adult homeostasis. Here we study the role of Syndecan-4 (SDC4), a cell-surface heparan sulphate proteoglycan, and Fibronectin (FN), in Wnt/beta-catenin signaling. Gain- and loss-of-function experiments in mammalian cell lines and Xenopus embryos demonstrate that SDC4 and FN inhibit Wnt/beta-catenin signaling. Epistatic and biochemical experiments show that this inhibition occurs at the cell membrane level through regulation of LRP6. R-spondin 3, a ligand that promotes canonical and non-canonical Wnt signaling, is more prone to potentiate Wnt/beta-catenin signaling when SDC4 levels are reduced, suggesting a model whereby SDC4 tunes the ability of R-spondin to modulate the different Wnt signaling pathways. Since SDC4 has been previously related to non-canonical Wnt signaling, our results also suggest that this proteoglycan can be a key component in the regulation of Wnt signaling. (C) 2013 Elsevier Ltd. All rights reserved. | |
| dc.fuente.origen | WOS | |
| dc.identifier.doi | 10.1016/j.biocel.2013.11.012 | |
| dc.identifier.eissn | 1878-5875 | |
| dc.identifier.issn | 1357-2725 | |
| dc.identifier.uri | https://doi.org/10.1016/j.biocel.2013.11.012 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/101753 | |
| dc.identifier.wosid | WOS:000330546600012 | |
| dc.language.iso | en | |
| dc.pagina.final | 112 | |
| dc.pagina.inicio | 103 | |
| dc.revista | International journal of biochemistry & cell biology | |
| dc.rights | acceso restringido | |
| dc.subject | Wnt | |
| dc.subject | Syndecan-4 | |
| dc.subject | LRP6 | |
| dc.subject | Fibronectin | |
| dc.subject | R-spondin | |
| dc.subject.ods | 03 Good Health and Well-being | |
| dc.subject.odspa | 03 Salud y bienestar | |
| dc.title | Syndecan-4 inhibits Wnt/β-catenin signaling through regulation of low-density-lipoprotein receptor-related protein (LRP6) and R-spondin 3 | |
| dc.type | artículo | |
| dc.volumen | 46 | |
| sipa.index | WOS | |
| sipa.trazabilidad | WOS;2025-01-12 |