Evaluation of Lung Aeration and Respiratory System Mechanics in Obese Dogs Ventilated With Tidal Volumes Based on Ideal vs. Current Body Weight

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dc.contributor.authorAraos, Joaquin
dc.contributor.authorLacitignola, Luca
dc.contributor.authorde Monte, Valentina
dc.contributor.authorStabile, Marzia
dc.contributor.authorPorter, Ian
dc.contributor.authorHurtado, Daniel E.
dc.contributor.authorPerez, Agustin
dc.contributor.authorCrovace, Antonio
dc.contributor.authorGrasso, Salvatore
dc.contributor.authorMartin-Flores, Manuel
dc.contributor.authorStaffieri, Francesco
dc.date.accessioned2025-01-20T22:06:40Z
dc.date.available2025-01-20T22:06:40Z
dc.date.issued2021
dc.description.abstractWe describe the respiratory mechanics and lung aeration in anesthetized obese dogs ventilated with tidal volumes (VT) based on ideal (VTi) vs. current (VTc) body weight. Six dogs with body condition scores >= 8/9 were included. End-expiratory respiratory mechanics and end-expiratory CT-scan were obtained at baseline for each dog. Thereafter, dogs were ventilated with VT 15 ml kg(-1) based on VTi and VTc, applied randomly. Respiratory mechanics and CT-scan were repeated at end-inspiration during VTi and VTc. Data analyzed with linear mixed models and reported as mean +/- SD or median [range]. Statistical significance p < 0.05. The elastance of the lung, chest wall and respiratory system indexed by ideal body weight (IBW) were positively correlated with body fat percentage, whereas the functional residual capacity indexed by IBW was negatively correlated with body fat percentage. At end-expiration, aeration (%) was: hyperaeration 0.03 [0.00-3.35], normoaeration 69.7 [44.6-82.2], hypoaeration 29.3 [13.6-49.4] and nonaeration (1.06% [0.37-6.02]). Next to the diaphragm, normoaeration dropped to 12 +/- 11% and hypoaeration increased to 90 +/- 8%. No differences in aeration between groups were found at end-inspiration. Airway driving pressure (cm H2O) was higher (p = 0.002) during VTc (9.8 +/- 0.7) compared with VTi (7.6 +/- 0.4). Lung strain was higher (p = 0.014) during VTc (55 +/- 21%) than VTi (38 +/- 10%). The stress index was higher (p = 0.012) during VTc (SI = 1.07 [0.14]) compared with VTi (SI = 0.93 [0.18]). This study indicates that body fat percentage influences the magnitude of lung, chest wall, and total respiratory system elastance and resistance, as well as functional residual capacity. Further, these results indicate that obese dogs have extensive areas of hypoaerated lungs, especially in caudodorsal regions. Finally, lung strain and airway driving pressure, surrogates of lung deformation, are higher during VTc than during VTi, suggesting that in obese anesthetized dogs, ventilation protocols based on IBW may be advantageous.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fvets.2021.704863
dc.identifier.eissn2297-1769
dc.identifier.urihttps://doi.org/10.3389/fvets.2021.704863
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94218
dc.identifier.wosidWOS:000708938700001
dc.language.isoen
dc.revistaFrontiers in veterinary science
dc.rightsacceso restringido
dc.subjectobese
dc.subjectdogs
dc.subjectmechanical ventilation
dc.subjectideal body weight
dc.subjectcurrent body weight
dc.subjectanesthesia
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEvaluation of Lung Aeration and Respiratory System Mechanics in Obese Dogs Ventilated With Tidal Volumes Based on Ideal vs. Current Body Weight
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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