Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19

Simple item page
dc.article.number760
dc.contributor.authorCeballos, María Elena
dc.contributor.authorNuñez, Ingrid
dc.contributor.authorUribe, Javier
dc.contributor.authorVera Alarcón, María Magdalena
dc.contributor.authorCastro López, Ricardo
dc.contributor.authorGarcía C., Patricia
dc.contributor.authorArriata, Gabriel
dc.contributor.authorGándara, Vicente
dc.contributor.authorVargas Muñoz, Camila
dc.contributor.authorDomínguez De Landa, María Angélica
dc.contributor.authorCerón, Inés
dc.contributor.authorBorn, Pablo
dc.contributor.authorEspíndola, Eduardo
dc.date.accessioned2022-11-03T15:44:44Z
dc.date.available2022-11-03T15:44:44Z
dc.date.issued2022
dc.date.updated2022-10-02T00:07:11Z
dc.description.abstractBackground: Patients with COVID-19 receiving mechanical ventilation may become aggravated with a secondary respiratory infection. The aim of this study was to describe secondary respiratory infections, their predictive factors, and outcomes in patients with COVID-19 requiring mechanical ventilation. Methods: A cohort study was carried out in a single tertiary hospital in Santiago, Chile, from 1st June to 31st July 2020. All patients with COVID-19 admitted to the intensive care unit that required mechanical ventilation were included. Results: A total of 175 patients were enrolled, of which 71 (40.6%) developed at least one secondary respiratory infection during follow-up. Early and late secondary infections were diagnosed in 1.7% and 31.4% respectively. Within late secondary infections, 88% were bacterial, 10% were fungal, and 2% were of viral origin. One-third of isolated bacteria were multidrug-resistant. Bivariate analysis showed that the history of corticosteroids used before admission and the use of dexamethasone during hospitalization were associated with a higher risk of secondary infections (p = 0.041 and p = 0.019 respectively). Multivariate analysis showed that for each additional day of mechanical ventilation, the risk of secondary infection increases 1.1 times (adOR = 1.07; 95% CI 1.02–1.13, p = 0.008) Conclusions: Patients with COVID-19 admitted to the intensive care unit and requiring mechanical ventilation had a high rate of secondary infections during their hospital stay. The number of days on MV was a risk factor for acquiring secondary respiratory infections.
dc.format.extent10 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationBMC Infectious Diseases. 2022 Sep 29;22(1):760
dc.identifier.doi10.1186/s12879-022-07743-2
dc.identifier.urihttps://doi.org/10.1186/s12879-022-07743-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/65304
dc.information.autorucFacultad de medicina ; Ceballos, María Elena ; 0000-0002-5569-6485 ; 190187
dc.information.autorucFacultad de medicina ; Nuñez, Ingrid ; S/I ; 1213951
dc.information.autorucFacultad de medicina ; Uribe, Javier ; S/I ; 205690
dc.information.autorucFacultad de medicina ; Vera Alarcón, María Magdalena ; S/I ; 226652
dc.information.autorucFacultad de medicina ; Castro López, Ricardo ; S/I ; 4537
dc.information.autorucFacultad de medicina ; García C., Patricia ; 0000-0002-3817-4896 ; 73909
dc.information.autorucFacultad de medicina ; Gándara, Vicente ; S/I ; 45377
dc.information.autorucFacultad de medicina ; Vargas Muñoz, Camila ; S/I ; 247634
dc.information.autorucEscuela de medicina ; Domínguez De Landa, María Angélica ; 0000-0001-7477-7574 ; 131798
dc.information.autorucFacultad de medicina ; Cerón, Inés ; S/I ; 9404
dc.information.autorucFacultad de medicina ; Born, Pablo ; S/I ; 223841
dc.information.autorucFacultad de medicina ; Espíndola, Eduardo ; S/I ; 103178
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final10
dc.pagina.inicio1
dc.revistaBMC Infectious Diseases
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectCoinfectionses_ES
dc.subjectSecondary infectionses_ES
dc.subjectCOVID-19es_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectICUes_ES
dc.subjectMechanical ventilationes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSecondary respiratory early and late infections in mechanically ventilated patients with COVID-19es_ES
dc.typeartículo
dc.volumen22
sipa.codpersvinculados190187
sipa.codpersvinculados1213951
sipa.codpersvinculados205690
sipa.codpersvinculados226652
sipa.codpersvinculados4537
sipa.codpersvinculados73909
sipa.codpersvinculados45377
sipa.codpersvinculados247634
sipa.codpersvinculados131798
sipa.codpersvinculados9404
sipa.codpersvinculados223841
sipa.codpersvinculados103178
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12879_2022_Article_7743.pdf
Size:
1.27 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos de revistas