Chronic stress impairs acoustic conditioning more than visual conditioning in rats: Morphological and behavioural evidence

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dc.contributor.authorDagnino Subiabre, A
dc.contributor.authorTerreros, G
dc.contributor.authorCarmona Fontaine, C
dc.contributor.authorZepeda, R
dc.contributor.authorOrellana, JA
dc.contributor.authorDiaz Veliz, G
dc.contributor.authorMora, S
dc.contributor.authorAboitiz, F
dc.date.accessioned2024-01-10T12:38:01Z
dc.date.available2024-01-10T12:38:01Z
dc.date.issued2005
dc.description.abstractChronic stress affects brain areas involved in learning and emotional responses. These alterations have been related with the development of cognitive deficits in major depression. The aim of this study was to determine the effect of chronic immobilization stress on the auditory and visual mesencephalic regions in the rat brain. We analyzed in Golgi preparations whether stress impairs the neuronal morphology of the inferior (auditory processing) and superior colliculi (visual processing). Afterward, we examined the effect of stress on acoustic and visual conditioning using an avoidance conditioning test. We found that stress induced dendritic atrophy in inferior colliculus neurons and did not affect neuronal morphology in the superior colliculus. Furthermore, stressed rats showed a stronger impairment in acoustic conditioning than in visual conditioning. Fifteen days post-stress the inferior colliculus neurons completely restored their dendritic structure, showing a high level of neural plasticity that is correlated with an improvement in acoustic learning. These results suggest that chronic stress has more deleterious effects in the subcortical auditory system than in the visual system and may affect the aversive system and fear-like behaviors. Our study opens a new approach to understand the pathophysiology of stress and stress-related disorders such as major depression. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.neuroscience.2005.07.032
dc.identifier.eissn1873-7544
dc.identifier.issn0306-4522
dc.identifier.pubmedidMEDLINE:16165300
dc.identifier.urihttps://doi.org/10.1016/j.neuroscience.2005.07.032
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76970
dc.identifier.wosidWOS:000232904900007
dc.information.autorucMedicina;Aboitiz F;S/I;100165
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1074
dc.pagina.inicio1067
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaNEUROSCIENCE
dc.rightsacceso restringido
dc.subjectstress
dc.subjectatrophy
dc.subjectinferior colliculus
dc.subjectplasticity
dc.subjectdepression
dc.subjectDENDRITIC REORGANIZATION
dc.subjectNEURONAL PLASTICITY
dc.subjectPYRAMIDAL NEURONS
dc.subjectHIPPOCAMPAL
dc.subjectORGANIZATION
dc.subjectCOLLICULUS
dc.subjectDEPRESSION
dc.subjectSECRETION
dc.subjectTHALAMUS
dc.subjectAMYGDALA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChronic stress impairs acoustic conditioning more than visual conditioning in rats: Morphological and behavioural evidence
dc.typeartículo
dc.volumen135
sipa.codpersvinculados100165
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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