Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation

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dc.catalogadordfo
dc.contributor.authorGiaume, Christian
dc.contributor.authorFroger, Nicolás
dc.contributor.authorOrellana Roca, Juan Andrés
dc.contributor.authorRetamal Lucero, Mauricio Antonio
dc.contributor.authorSaéz Carreño, Juan Carlos
dc.date.accessioned2024-10-17T18:44:33Z
dc.date.available2024-10-17T18:44:33Z
dc.date.issued2013
dc.description.abstractThe central nervous system (CNS) is capable of dynamic immune and inŽammatory responses mediated by the activation of microglia, the brain resident macrophage population, and astrocyte reactivity. A growing body of evidence shows that the innate immune response exerts a dichotomous role in the brain. Under physiological conditions, microglia exhibit a resting phenotype that is associated with the production of anti-inŽammatory and neurotrophic factors. Microglia shift to an activated phenotype in response to a wide range of insults that activate speciŸc signaling pathways, thereby promoting an inŽammatory response necessary to further engage the immune system. The sustained inŽammation resulting in brain injury and pathology
dc.description.funderFONDECYT
dc.format.extent14 páginas
dc.fuente.origenHistorial Académico
dc.identifier.citationGiaume C, Froger N, Orellana JA, Retamal M, Saez JC. Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation. In: Oviedo-Orta, Kwak and Evans,editors. Connexin cell communication channels: roles on the immune system and immunopathology. Estados Unidos: Taylor and Francis publisher; 2013. p. 219-232.
dc.identifier.eisbn9780429165856
dc.identifier.isbn9781439862575
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88280
dc.identifier.wosidWOS:000353658900013
dc.information.autorucFacultad de Ciencias Biológicas; Orellana Roca Juan Andres; 0000-0003-4076-207X; 126007
dc.information.autorucFacultad de Ciencias Biológicas; Retamal Lucero Mauricio Antonio; S/I; 127950
dc.information.autorucFacultad de Ciencias Biológicas; Saez Carreno Juan Carlos; 0000-0003-3811-0347; 99913
dc.language.isoen
dc.lugar.publicacionEstados Unidos
dc.nota.accesoContenido parcial
dc.pagina.final232
dc.pagina.inicio219
dc.publisherTaylor and Francis publisher
dc.relation.ispartofConnexin cell communication channels: roles on the immune system and immunopathology
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImpact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation
dc.typecapítulo de libro
sipa.codpersvinculados126007
sipa.codpersvinculados127950
sipa.codpersvinculados99913
sipa.trazabilidadHistorial Académico;09-07-2021
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