Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection

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dc.contributor.authorEsteves Ribeiro, Grazielle
dc.contributor.authorEdgardo Leon, Luis
dc.contributor.authorPerez, Ruth
dc.contributor.authorCuiza, Analia
dc.contributor.authorAgustin Vial, Pablo
dc.contributor.authorFerres, Marcela
dc.contributor.authorMertz, Gregory J.
dc.contributor.authorVial, Cecilia
dc.date.accessioned2025-01-23T21:11:17Z
dc.date.available2025-01-23T21:11:17Z
dc.date.issued2019
dc.description.abstractAndes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others have a mild clinical course. The main goal of this study was to understand if the genetic variation of patients is associated with the clinical course they develop after ANDV infection. For this, the frequency of copy number variants (CNVs, i.e., deletions and duplications) was studied in 195 patients, 88 with mild and 107 with severe HCPS. CNVs were called from intensity data of the Affymetrix Genome-Wide SNP Array 6.0. The analysis of the data was performed with PennCNV, ParseCNV and R softwares; Results: a deletion of 19, 416 bp in the q31.3 region of chromosome 1 is found more frequently in severe patients (p < 0.05). This region contains Complement Factor H Related (CFHR1) and CFHR3 genes, regulators of the complement cascade. A second deletion of 1.81 kb located in the p13 region of chr20 was significantly more frequent in mild patients (p < 0.05). This region contains the SIRPB1 gene, which participates in the innate immune response, more specifically in neutrophil trans-epithelial migration. Both deletions are associated with the clinical course of HCPS, the first being a risk factor and the second being protective. The participation of genes contained in both deletions in ANDV infection pathophysiology deserves further investigation.
dc.fuente.origenWOS
dc.identifier.doi10.3390/v11080680
dc.identifier.eissn1999-4915
dc.identifier.urihttps://doi.org/10.3390/v11080680
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100898
dc.identifier.wosidWOS:000482993900039
dc.issue.numero8
dc.language.isoen
dc.revistaViruses-basel
dc.rightsacceso restringido
dc.subjectHCPS
dc.subjectANDV
dc.subjecthantavirus
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDeletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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