Aortic Stenosis: Haemodynamic Benchmark and Metric Reliability Study

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dc.contributor.authorGill, Harminder
dc.contributor.authorFernandes, Joao Filipe
dc.contributor.authorNio, Amanda
dc.contributor.authorDockerill, Cameron
dc.contributor.authorShah, Nili
dc.contributor.authorAhmed, Naajia
dc.contributor.authorRaymond, Jason
dc.contributor.authorWang, Shu
dc.contributor.authorSotelo, Julio
dc.contributor.authorUrbina, Jesus
dc.contributor.authorUribe, Sergio
dc.contributor.authorRajani, Ronak
dc.contributor.authorRhode, Kawal
dc.contributor.authorLamata, Pablo
dc.date.accessioned2025-01-20T20:18:01Z
dc.date.available2025-01-20T20:18:01Z
dc.date.issued2023
dc.description.abstractAortic stenosis is a condition which is fatal if left untreated. Novel quantitative imaging techniques which better characterise transvalvular pressure drops are being developed but require refinement and validation. A customisable and cost-effective workbench valve phantom circuit capable of replicating valve mechanics and pathology was created. The reproducibility and relationship of differing haemodynamic metrics were assessed from ground truth pressure data alongside imaging compatibility. The phantom met the requirements to capture ground truth pressure data alongside ultrasound and magnetic resonance image compatibility. The reproducibility was successfully tested. The robustness of three different pressure drop metrics was assessed: whilst the peak and net pressure drops provide a robust assessment of the stenotic burden in our phantom, the peak-to-peak pressure drop is a metric that is confounded by non-valvular factors such as wave reflection. The peak-to-peak pressure drop is a metric that should be reconsidered in clinical practice.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12265-022-10350-w
dc.identifier.eissn1937-5395
dc.identifier.issn1937-5387
dc.identifier.urihttps://doi.org/10.1007/s12265-022-10350-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92435
dc.identifier.wosidWOS:000927570900003
dc.issue.numero4
dc.language.isoen
dc.pagina.final873
dc.pagina.inicio862
dc.revistaJournal of cardiovascular translational research
dc.rightsacceso restringido
dc.subjectHaemodynamics
dc.subjectAortic valve
dc.subjectAortic stenosis
dc.subject3D printing
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAortic Stenosis: Haemodynamic Benchmark and Metric Reliability Study
dc.typeartículo
dc.volumen16
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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