Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis

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dc.catalogadorgjm
dc.contributor.authorCastiblanco Galvis, Adriana
dc.contributor.authorPires, Yumay
dc.contributor.authorWistuba Oyarzún, Ignacio
dc.contributor.authorRiquelme Sánchez, Erick Marcelo
dc.contributor.authorAndrade M., Leonardo
dc.contributor.authorCorvalán R., Alejandro
dc.date.accessioned2024-06-04T17:45:34Z
dc.date.available2024-06-04T17:45:34Z
dc.date.issued2006
dc.description.abstractBackground: Endomeotrioid carcinoma and clear cell carcinoma of the ovary are associated to endometriosis. Somatic mutations of PTEN (10q23.3) are present in endothelial endometrioid carcinoma. Therefore, these mutations could be also present in ovarian tumors Molecular studies show that solitary endometriotic cysts are monoclonal, have aneuploid DNA, have a loss of 9p, 11q and 22q heterozygosity (LOH) and a higher cellular proliferation index of the epithelial component. Aim: To determine the cellular proliferation index using Ki 67, the immunohistochemical expression of PTEN and LOH in patients with ovarian endometriosis without atypia (EN), ovarian endometriosis with atypia (P-A) and endometriosis with adjacent ovarian carcinoma (0). Material and methods: Paraffin embedded samples of 37 endometrioid and clear cell carcinomas of the ovary (CC/CE), 15 solitary ovarian EN and 15 ovarian EA, were studied. Expression of Ki 67 and PTEN was measured by immunohistochemistry. LOH of 10q23-3 locus was measured by polymerase chain reaction. Results: Ki 67 was 5.5 and 23% in EA and EN, respectively (p < 0.005). There was a histological correlation between LA and a higher cellular proliferation index. PTEN was negative in 5 of 15 EN, 9 of 15 EA and 30 of 37 CE/CC. There was a correlation between LOH and loss of PTEN protein in EN, EA and ET(60%), Conclusions: Negative expression on PTEN in EN; EA; ET and CE/CC is a manifestation of the inactivation of this gene. The mechanisms that cause this inactivation, must be elucidated.
dc.fechaingreso.objetodigital2024-06-04
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:16676097
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86399
dc.identifier.wosidWOS:000237363400001
dc.information.autorucEscuela de Medicina; Castiblanco Galvis, Adriana; S/I; 129223
dc.information.autorucEscuela de Medicina; Pires, Yumay; S/I; 53
dc.information.autorucEscuela de Medicina; Wistuba Oyarzún, Ignacio; S/I; 100278
dc.information.autorucEscuela de Medicina; Riquelme Sánchez, Erick Marcelo; 0000-0002-2696-7995; 1001194
dc.information.autorucEscuela de Medicina; Andrade M., Leonardo; S/I; 115693
dc.information.autorucEscuela de Medicina; Corvalán R., Alejandro; 0000-0001-5492-3853; 63885
dc.issue.numero3
dc.language.isoes
dc.nota.accesocontenido completo
dc.pagina.final278
dc.pagina.inicio271
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEndometrial neoplasms
dc.subjectEndometriosis
dc.subjectOvarian neoplasms
dc.subjectPTEN protein, human
dc.titleRol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
dc.title.alternativePathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis
dc.typeartículo
dc.volumen134
sipa.codpersvinculados129223
sipa.codpersvinculados53
sipa.codpersvinculados100278
sipa.codpersvinculados1001194
sipa.codpersvinculados115693
sipa.codpersvinculados63885
sipa.trazabilidadWOS;05-06-2021
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