Extracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy

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dc.article.number817
dc.catalogadorgjm
dc.contributor.authorHernández Villanueva, Alejandra Andrea
dc.contributor.authorArab Verdugo, Juan Pablo
dc.contributor.authorReyes, Daniela
dc.contributor.authorLapitz, Ainhoa
dc.contributor.authorMoshage, Han
dc.contributor.authorBañales, Jesús M.
dc.contributor.authorArrese, Marco
dc.date.accessioned2024-07-18T14:51:35Z
dc.date.available2024-07-18T14:51:35Z
dc.date.issued2020
dc.description.abstractIn recent years, knowledge on the biology and pathobiology of extracellular vesicles (EVs) has exploded. EVs are submicron membrane-bound structures secreted from different cell types containing a wide variety of bioactive molecules (e.g., proteins, lipids, and nucleic acids (coding and non-coding RNA) and mitochondrial DNA). EVs have important functions in cell-to-cell communication and are found in a wide variety of tissues and body fluids. Better delineation of EV structures and advances in the isolation and characterization of their cargo have allowed the diagnostic and therapeutic implications of these particles to be explored. In the field of liver diseases, EVs are emerging as key players in the pathogenesis of both nonalcoholic liver disease (NAFLD) and alcoholic liver disease (ALD), the most prevalent liver diseases worldwide, and their complications, including development of hepatocellular carcinoma. In these diseases, stressed/damaged hepatocytes release large quantities of EVs that contribute to the occurrence of inflammation, fibrogenesis, and angiogenesis, which are key pathobiological processes in liver disease progression. Moreover, the specific molecular signatures of released EVs in biofluids have allowed EVs to be considered as promising candidates to serve as disease biomarkers. Additionally, different experimental studies have shown that EVs may have potential for therapeutic use as a liver-specific delivery method of different agents, taking advantage of their hepatocellular uptake through interactions with specific receptors. In this review, we focused on the most recent findings concerning the role of EVs as new structures mediating autocrine and paracrine intercellular communication in both ALD and NAFLD, as well as their potential use as biomarkers of disease severity and progression. Emerging therapeutic applications of EVs in these liver diseases were also examined, along with the potential for successful transition from bench to clinic.
dc.fechaingreso.objetodigital2024-07-18
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/cells9040817
dc.identifier.eissn2073-4409
dc.identifier.issn2073-4409
dc.identifier.pubmedid32231001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87109
dc.identifier.wosidWOS:000535559500028
dc.information.autorucEscuela de Medicina; Hernández Villanueva, Alejandra Andrea; S/I; 179063
dc.information.autorucEscuela de Medicina; Arab Verdugo, Juan Pablo; 0000-0002-8561-396X; 132745
dc.information.autorucEscuela de Medicina; Arrese, Marco; 0000-0002-0499-4191; 76095
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaCells
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNonalcoholic fatty liver disease
dc.subjectFatty liver
dc.subjectAlcoholic liver disease
dc.subjectExtracellular vesicles
dc.subjectSignaling
dc.subjectExosomes
dc.subjectBiomarkers
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy
dc.typeartículo de revisión
dc.volumen9
sipa.codpersvinculados179063
sipa.codpersvinculados132745
sipa.codpersvinculados76095
sipa.trazabilidadORCID;2024-07-15
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