A single-cell atlas of murine reproductive tissues during preterm labor

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dc.contributor.authorGarcia-Flores, Valeria
dc.contributor.authorRomero, Roberto
dc.contributor.authorPeyvandipour, Azam
dc.contributor.authorGalaz, Jose
dc.contributor.authorPusod, Errile
dc.contributor.authorPanaitescu, Bogdan
dc.contributor.authorMiller, Derek
dc.contributor.authorXu, Yi
dc.contributor.authorTao, Li
dc.contributor.authorLiu, Zhenjie
dc.contributor.authorTarca, Adi L.
dc.contributor.authorPique-Regi, Roger
dc.contributor.authorGomez-Lopez, Nardhy
dc.date.accessioned2025-01-20T20:15:42Z
dc.date.available2025-01-20T20:15:42Z
dc.date.issued2023
dc.description.abstractPreterm birth, the leading cause of perinatal morbidity and mortality worldwide, frequently results from the syndrome of preterm labor. The best-established causal link to preterm labor is intra-amniotic infection, which involves premature activation of the parturition cascade in the reproductive tissues. Herein, we utilize single-cell RNA sequencing (scRNA-seq) to generate a single-cell atlas of the murine uterus, decidua, and cervix in a model of infection-induced preterm labor. We show that preterm labor affects the transcriptomic profiles of specific immune and non-immune cell subsets. Shared and tissue-specific gene expression sig-natures are identified among affected cells. Determination of intercellular communications implicates spe-cific cell types in preterm labor-associated signaling pathways across tissues. In silico comparison of murine and human uterine cell-cell interactions reveals conserved signaling pathways implicated in labor. Thus, our scRNA-seq data provide insights into the preterm labor-driven cellular landscape and communications in reproductive tissues.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.celrep.2022.111846
dc.identifier.issn2211-1247
dc.identifier.urihttps://doi.org/10.1016/j.celrep.2022.111846
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92278
dc.identifier.wosidWOS:000966533900001
dc.issue.numero1
dc.language.isoen
dc.revistaCell reports
dc.rightsacceso restringido
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleA single-cell atlas of murine reproductive tissues during preterm labor
dc.typeartículo
dc.volumen42
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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