Sex Differences in Fetal Growth Responses to Maternal Height and Weight

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dc.contributor.authorLampl, Michelle
dc.contributor.authorGotsch, Francesca
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorGomez, Ricardo
dc.contributor.authorKae Nien, Jyh
dc.contributor.authorFrongillo, Edward A.
dc.contributor.authorRomero, Roberto
dc.date.accessioned2024-01-10T12:42:33Z
dc.date.available2024-01-10T12:42:33Z
dc.date.issued2010
dc.description.abstractSex differences in fetal growth have been reported, but how this happens remains to be described. It is unknown if fetal growth rates, a reflection of genetic and environmental factors, express sexually dimorphic sensitivity to the mother herself. This analysis investigated homogeneity of male and female growth responses to maternal height and weight. The study sample included 3,495 uncomplicated singleton pregnancies followed longitudinally. Analytic models regressed fetal and neonatal weight on tertiles of maternal height and weight, and modification by sex was investigated (n = 1,814 males, n = 1,681 females) with birth gestational age, maternal parity, and smoking as covariates. Sex modified the effects of maternal height and weight on fetal growth rates and birth weight. Among boys, tallest maternal height influenced fetal weight growth before 18 gestational weeks of age (P = 0.006), and prepregnancy maternal weight and body mass index subsequently had influence (P < 0.001); this was not found among girls. Additionally, interaction terms between sex, maternal height, and maternal weight identified that males were more sensitive to maternal weight among shorter mothers (P = 0.003) and more responsive to maternal height among lighter mothers (P <= 0.03), compared to females. Likewise, neonatal birth weight dimorphism varied by maternal phenotype. A male advantage of 60 g occurred among neonates of the shortest and lightest mothers (P = 0.08), compared to 150 and 191 g among short and heavy mothers, and tall and light-weight mothers, respectively (P = 0.01). Sex differences in response to maternal size are under-appreciated sources of variation in fetal growth studies and may reflect differential growth strategies. Am. J. Hum. Biol. 22:431-443, 2010. (C) 2009 Wiley-Liss, Inc.
dc.description.funderPerinatology Research Branch; Division of Intramural Research; Eunice Kennedy Shriven; National Institute of Child Health and Human Development; NIH; DHHS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.fechaingreso.objetodigital02-04-2024
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ajhb.21014
dc.identifier.eissn1520-6300
dc.identifier.issn1042-0533
dc.identifier.pubmedidMEDLINE:19950190
dc.identifier.urihttps://doi.org/10.1002/ajhb.21014
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77521
dc.identifier.wosidWOS:000278878300001
dc.information.autorucMedicina;Gómez R;S/I;80926
dc.information.autorucMedicina;Nien Shy J;S/I;2778
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final443
dc.pagina.inicio431
dc.publisherWILEY
dc.revistaAMERICAN JOURNAL OF HUMAN BIOLOGY
dc.rightsacceso restringido
dc.subjectLOW-BIRTH-WEIGHT
dc.subjectGESTATIONAL-AGE
dc.subjectINTRAUTERINE GROWTH
dc.subjectPROSPECTIVE COHORT
dc.subjectMALE PREDOMINANCE
dc.subjectPLACENTAL VOLUME
dc.subjectRISK-FACTORS
dc.subjectPREGNANCY
dc.subjectGENDER
dc.subjectGAIN
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleSex Differences in Fetal Growth Responses to Maternal Height and Weight
dc.typeartículo
dc.volumen22
sipa.codpersvinculados80926
sipa.codpersvinculados2778
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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