Molecular alterations in primary prostate cancer after androgen ablation therapy

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dc.contributor.authorBest, CJM
dc.contributor.authorGillespie, JW
dc.contributor.authorYi, YJ
dc.contributor.authorChandramouli, GVR
dc.contributor.authorPerlmutter, MA
dc.contributor.authorGathright, Y
dc.contributor.authorErickson, HS
dc.contributor.authorGeorgevich, L
dc.contributor.authorTangrea, MA
dc.contributor.authorDuray, PH
dc.contributor.authorGonzalez, S
dc.contributor.authorVelasco, A
dc.contributor.authorLinehan, WM
dc.contributor.authorMatusik, RJ
dc.contributor.authorPrice, DK
dc.contributor.authorFigg, WD
dc.contributor.authorEmmert Buck, MR
dc.contributor.authorChuaqui, RF
dc.date.accessioned2024-01-10T13:15:05Z
dc.date.available2024-01-10T13:15:05Z
dc.date.issued2005
dc.description.abstractPurpose: After an initial response to androgen ablation, most prostate tumors recur, ultimately progressing to highly aggressive androgen-independent cancer. The molecular mechanisms underlying progression are not well known in part due to the rarity of androgen-independent Samples from primary and-metastatic sites.
dc.description.abstractExperimental Design: We compared the gene expression profiles of 10 androgen-independent primary prostate tumor biopsies with 10 primary, untreated androgen-dependent tumors. Samples were laser capture microdissected, the RNA was amplified, and gene expression was assessed using Affymetrix Human Genome U133A GeneChip. Differential expression was examined with principal component analysis, hierarchical clustering', and Student's t testing. Analysis of gene ontology was done with Expression Analysis Systematic Explorer and gene expression data were integrated with genomic alterations with Differential Gene Locus Mapping.
dc.description.abstractResults: Unsupervised principal component analysis showed that the androgen-dependent and androgen-independent tumors segregated from one another. After filtering the data, 239 differentially expressed genes were identified. Two main gene ontologies were found discordant between androgen-independent and androgen-dependent tumors-macromolecule biosynthesis was clown-regulated and cell adhesion was up-regulated in androgen-independent tumors. Other differentially expressed genes were related to interleukin-6 signaling as well as angiogenesis, cell adhesion, apoptosis, oxidative stress, and hormone response. The Differential Gene Locus Mapping analysis identified nine regions of potential chromosomal deletion in the androgen-independent tumors, including 1p36, 3p2l, 6p2l, 8p2l, 11p15, 11q12,12q23,16q12, and 16q2l.
dc.description.abstractConclusions: Taken together, these data identify several unique characteristics of androgen-independent prostate cancer that may hold potential for the devellopment,of targeted therapeutic intervention.
dc.description.funderDIVISION OF BASIC SCIENCES - NCI
dc.description.funderDIVISION OF CLINICAL SCIENCES - NCI
dc.description.funderNATIONAL CANCER INSTITUTE
dc.description.funderIntramural NIH HHS
dc.description.funderNCI NIH HHS
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1158/1078-0432.CCR-05-0585
dc.identifier.eissn1557-3265
dc.identifier.issn1078-0432
dc.identifier.pubmedidMEDLINE:16203770
dc.identifier.urihttps://doi.org/10.1158/1078-0432.CCR-05-0585
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78469
dc.identifier.wosidWOS:000232238100013
dc.information.autorucMedicina;González S;S/I;99856
dc.information.autorucMedicina;Velasco A;S/I;58191
dc.issue.numero19
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final6834
dc.pagina.inicio6823
dc.publisherAMER ASSOC CANCER RESEARCH
dc.revistaCLINICAL CANCER RESEARCH
dc.rightsacceso restringido
dc.subjectGENE-EXPRESSION ANALYSIS
dc.subjectLASER CAPTURE MICRODISSECTION
dc.subjectCDNA MICROARRAY ANALYSIS
dc.subjectDEPRIVATION THERAPY
dc.subjectNEUROENDOCRINE DIFFERENTIATION
dc.subjectTUMOR ANGIOGENESIS
dc.subjectALLELIC LOSS
dc.subjectCELL-LINES
dc.subjectBCL-X
dc.subjectGROWTH
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMolecular alterations in primary prostate cancer after androgen ablation therapy
dc.typeartículo
dc.volumen11
sipa.codpersvinculados99856
sipa.codpersvinculados58191
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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