Use of methylene blue in patients with refractory septic shock: Impact on hemodynamics and gas exchange

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dc.contributor.authorAndresen, M
dc.contributor.authorDougnac, A
dc.contributor.authorDiaz, O
dc.contributor.authorHernandez, G
dc.contributor.authorCastillo, L
dc.contributor.authorBugedo, G
dc.contributor.authorAlvarez, M
dc.contributor.authorDagnino, J
dc.date.accessioned2024-01-10T13:44:06Z
dc.date.available2024-01-10T13:44:06Z
dc.date.issued1998
dc.description.abstractPurpose: The purpose of this study was to assess the acute effects of methylene blue, an inhibitor of nitric oxide synthesis, on hemodynamics and gas exchange in patients with refractory septic shock in a prospective clinical trial at medical and surgical intensive care units in a tertiary university hospital.
dc.description.abstractPatients and Methods: Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs. Six of them also developed acute lung injury. All received 1 mg/kg intravenous bolus of methylene blue. Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection.
dc.description.abstractResults: Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio. Gas exchange remained unaffected in patients with acute lung injury.
dc.description.abstractConclusions: Methylene blue had an acute vasopressor effect in patients with refractory septic shock, and it was not deleterious on respiratory function, Copyright (C) 1998 by W.B. Saunders Company.
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0883-9441(98)90001-6
dc.identifier.issn0883-9441
dc.identifier.pubmedidMEDLINE:9869542
dc.identifier.urihttps://doi.org/10.1016/S0883-9441(98)90001-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78841
dc.identifier.wosidWOS:000077481900002
dc.information.autorucMedicina;Andresen M;S/I;54274
dc.information.autorucMedicina;Bugedo G;S/I;60490
dc.information.autorucMedicina;Castillo L;S/I;54397
dc.information.autorucMedicina;Dagnino J;S/I;98860
dc.information.autorucMedicina;Díaz O;S/I;78564
dc.information.autorucMedicina;Hernández G;S/I;98874
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final168
dc.pagina.inicio164
dc.publisherW B SAUNDERS CO
dc.revistaJOURNAL OF CRITICAL CARE
dc.rightsacceso restringido
dc.subjectNITRIC-OXIDE SYNTHESIS
dc.subjectL-ARGININE
dc.subjectVASCULAR-RESISTANCE
dc.subjectSEPSIS SYNDROME
dc.subjectENDOTOXIN
dc.subjectINHIBITION
dc.subjectSYNTHASE
dc.subjectENDOTHELIUM
dc.subjectMECHANISMS
dc.subjectREVERSAL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUse of methylene blue in patients with refractory septic shock: Impact on hemodynamics and gas exchange
dc.typeartículo
dc.volumen13
sipa.codpersvinculados54274
sipa.codpersvinculados60490
sipa.codpersvinculados54397
sipa.codpersvinculados98860
sipa.codpersvinculados78564
sipa.codpersvinculados98874
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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