Differences in the composition and predicted functions of the intestinal microbiome of obese and normal weight adult dogs

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dc.contributor.authorThomson, Pamela
dc.contributor.authorSantibanez, Rodrigo
dc.contributor.authorRodriguez-Salas, Camila
dc.contributor.authorFlores-Yanez, Carla
dc.contributor.authorGarrido, Daniel
dc.date.accessioned2025-01-20T21:12:30Z
dc.date.available2025-01-20T21:12:30Z
dc.date.issued2022
dc.description.abstractObesity is a multifactorial nutritional disorder highly prevalent in dogs, observed in developed and developing countries. It is estimated that over 40% of the canine population suffers from obesity, which manifests in an increased risk of chronic osteoarticular, metabolic, and cardiovascular diseases. The intestinal microbiome of obese animals shows increases in the abundance of certain members capable of extracting energy from complex polysaccharides. The objective of this study was to compare the composition and predicted function of the intestinal microbiome of Chilean obese and normal weight adult dogs. Twenty clinically healthy dogs were classified according to their body condition score (BCS) as obese (n = 10) or normal weight (n = 10). DNA was extracted from stool samples, followed by next-generation sequencing of the 16S rRNA V3-V4 region and bioinformatics analysis targeting microbiome composition and function. Significant differences were observed between these groups at the phylum level, with anincrease in Firmicutes and a decrease in Bacteroidetes in obese dogs. Microbiome compositions of these animals correlated with their BCS, and obese dogs showed enrichment in pathways related to transport, chemotaxis, and flagellar assembly. These results highlight the differences in the gut microbiome between normal weight and obese dogs and prompt further research to improve animal health by modulating the gut microbiome.
dc.fuente.origenWOS
dc.identifier.doi10.7717/peerj.12695
dc.identifier.issn2167-8359
dc.identifier.urihttps://doi.org/10.7717/peerj.12695
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93662
dc.identifier.wosidWOS:000756689100004
dc.language.isoen
dc.revistaPeerj
dc.rightsacceso restringido
dc.subjectObesity
dc.subjectGut microbiome
dc.subjectCanines
dc.subjectMicrobiome function
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferences in the composition and predicted functions of the intestinal microbiome of obese and normal weight adult dogs
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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