ATP- and ACh-induced responses in isolated cat petrosal ganglion neurons

Simple item page
dc.contributor.authorAlcayaga, Carmen
dc.contributor.authorVaras, Rodrigo
dc.contributor.authorValdes, Viviana
dc.contributor.authorCerpa, Veronica
dc.contributor.authorArroyo, Jorge
dc.contributor.authorIturriaga, Rodrigo
dc.contributor.authorAlcayaga, Julio
dc.date.accessioned2025-01-21T01:05:38Z
dc.date.available2025-01-21T01:05:38Z
dc.date.issued2007
dc.description.abstractChemoreceptor (glomus) cells of the carotid body are synaptically connected to the sensory nerve endings of petrosal ganglion (PG) neurons. In response to natural stimuli, the glomus cells release transmitters, which acting on the nerve terminals of petrosal neurons increases the chemosensory afferent discharge. Among several transmitter molecules present in glomus cells, acetylcholine (ACh) and adenosine 5'-triphosphate (ATP) are considered to act as excitatory transmitter in this synapse. To test if ACh and ATP play a role as excitatory transmitters in the cat CB, we recorded the electrophysiological responses from PG neurons cultured in vitro. Under voltage clamp, ATP induces a concentration-dependent inward current that partially desensitizes during 20-30 s application pulses. The ATP-induced current has a threshold near 100 nM and saturates between 20-50 mu M. ACh induces a fast, inactivating inward current, with a threshold between 10-50 mu M, and saturates around 1 mM. A large part of the population of PG neurons (60%) respond to both ATP and ACh. Present results support the hypothesis that ACh and ATP act as excitatory transmitters between cat glomus cells and PG neurons. (c) 2006 Elsevier B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.brainres.2006.11.012
dc.identifier.eissn1872-6240
dc.identifier.issn0006-8993
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2006.11.012
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95978
dc.identifier.wosidWOS:000244011900007
dc.issue.numero1
dc.language.isoen
dc.pagina.final67
dc.pagina.inicio60
dc.revistaBrain research
dc.rightsacceso restringido
dc.subjectACh
dc.subjectATP
dc.subjectcarotid body
dc.subjectpetrosal ganglion
dc.subjectsensory neuron
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleATP- and ACh-induced responses in isolated cat petrosal ganglion neurons
dc.typeartículo
dc.volumen1131
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas