Sex disparities in gallstone disease: insights from the MAUCO prospective population-based cohort study

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dc.contributor.authorGatta, Danae Rodriguez
dc.contributor.authorHuidobro, Laura
dc.contributor.authorPetermann-Rocha, Fanny
dc.contributor.authorVan de Wyngard, Vanessa
dc.contributor.authorGodoy, Franco
dc.contributor.authorCid, Vicente
dc.contributor.authorGarrido, Macarena
dc.contributor.authorCook, Paz
dc.contributor.authorRoa, Juan Carlos
dc.contributor.authorVargas, Claudio
dc.contributor.authorAraya, Juan Carlos
dc.contributor.authorCortes, Sandra
dc.contributor.authorCruz, Francisco
dc.contributor.authorKoshiol, Jill
dc.contributor.authorArrese, Marco
dc.contributor.authorFerreccio, Catterina
dc.date.accessioned2025-01-20T16:07:38Z
dc.date.available2025-01-20T16:07:38Z
dc.date.issued2024
dc.description.abstractObjective To investigate factors associated with the prevalence and incidence of gallstone disease (GSD) in women and men of the MAUCO population-based prospective cohort. Design 8948 MAUCO participants (aged 38-74 years) underwent abdominal ultrasound at baseline (2015-2019); 4385 received follow-up ultrasound at years 2 or 4. Factors associated with prevalent GSD were assessed using Poisson multiple regression and with incident GSD using Cox regression models. Results GSD prevalence was 40.4% in women (13.1% gallstones, 27.3% cholecystectomies) and 17.1% in men (8.9% gallstones, 8.2% cholecystectomies). In men, GSD prevalence rate ratio (PRR) by age in >64 years was 3.85 (95% CI 3.00 to 4.94), doubling that of women's PRR 1.78 (95% CI 1.57 to 2.01). In women, waist circumference and diabetes were stronger GSD factors; a higher number of children and worse metabolic and socioeconomic conditions were also highlighted. GSD men had higher cardiovascular disease and a family history of GSD and gallbladder cancer. 198 GSD cases developed during follow-up, with incidence increasing by 2% (95% CI 1.005% to 1.03%) per each centimetre above the ideal waist circumference, statistically significant only in women. In men, age was the strongest factor for incidence, followed by a family history of GSD and low high-density lipoprotein increased incidence risk. Conclusions GSD burden was high in this population; a third of women had their gallbladder removed, which may pose them at risk of other health problems. Abdominal obesity was the only preventable GSD risk factor, highlighting the need for effective public health policies promoting obesity reduction.
dc.fuente.origenWOS
dc.identifier.doi10.1136/bmjgast-2024-001457
dc.identifier.issn2054-4774
dc.identifier.urihttps://doi.org/10.1136/bmjgast-2024-001457
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90011
dc.identifier.wosidWOS:001325110500001
dc.issue.numero1
dc.language.isoen
dc.revistaBmj open gastroenterology
dc.rightsacceso restringido
dc.subjectGALLSTONE DISEASE
dc.subjectGALLSTONES
dc.subjectCHOLECYSTECTOMY
dc.subjectOBESITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSex disparities in gallstone disease: insights from the MAUCO prospective population-based cohort study
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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