Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Simple item page
dc.article.number2537
dc.catalogadorgjm
dc.contributor.authorKau, Drishti
dc.contributor.authorRathnasinghe, Raveen Shevantha
dc.contributor.authorFerrés, Marcela
dc.contributor.authorTan, Gene S.
dc.contributor.authorBarrera Vásquez, Aldo Vincent
dc.contributor.authorPickett, Brett E.
dc.contributor.authorMethe, Barbara A.
dc.contributor.authorDas, Suman
dc.contributor.authorBudnik Ojeda, Isolda Cecilia
dc.contributor.authorHalpin, Rebecca A.
dc.contributor.authorWentworth, David
dc.contributor.authorSchmolke, Mirco
dc.contributor.authorMena, Ignacio
dc.contributor.authorAlbrecht, Randy A.
dc.contributor.authorSingh, Indresh
dc.contributor.authorNelson, Karen E.
dc.contributor.authorGarcia Sastre, Adolfo
dc.contributor.authorDupont, Chris L.
dc.contributor.authorMedina, Rafael
dc.date.accessioned2025-03-06T18:55:14Z
dc.date.available2025-03-06T18:55:14Z
dc.date.issued2020
dc.description.abstractInfection with influenza can be aggravated by bacterial co-infections, which often results in disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) microbiome are largely unknown. Here, we report a longitudinal study to assess the temporal dynamics of the URT microbiomes of uninfected and influenza virus-infected humans and ferrets. Uninfected human patients and ferret URT microbiomes have stable healthy ecostate communities both within and between individuals. In contrast, infected patients and ferrets exhibit large changes in bacterial community composition over time and between individuals. The unhealthy ecostates of infected individuals progress towards the healthy ecostate, coinciding with viral clearance and recovery. Pseudomonadales associate statistically with the disturbed microbiomes of infected individuals. The dynamic and resilient microbiome during influenza virus infection in multiple hosts provides a compelling rationale for the maintenance of the microbiome homeostasis as a potential therapeutic target to prevent IAV associated bacterial co-infections. Influenza A virus (IAV) infection can be exacerbated by bacterial co-infections but the effect of IAV on the upper respiratory tract (URT) microbiome remains unclear. Here, the authors compare the dynamics of the UTR microbiome in IAV-infected ferrets and humans, finding similar trends at the ecosystem and individual taxon level in both hosts.
dc.description.funderNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services
dc.description.funderComision Nacional de Investigacion Cientifica y Tecnologica (FONDECYT)
dc.description.funderChilean Ministry of Economy, Development and Tourism
dc.description.funderCRIP (Center for Research in Influenza Pathogenesis)
dc.description.funderNIAID funded Center of Excellence for Influenza Research and Surveillance (CEIRS)
dc.description.funderNIAID
dc.fechaingreso.objetodigital2025-03-06
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41467-020-16429-9
dc.identifier.issn2041-1723
dc.identifier.pubmedidMEDLINE:32439901
dc.identifier.urihttps://doi.org/10.1038/s41467-020-16429-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102409
dc.identifier.wosidWOS:000537066900009
dc.information.autorucActividades Universitarias-Dri; Rathnasinghe, Raveen Shevantha; S/I; 245038
dc.information.autorucEscuela de Medicina; Ferrés, Marcela; 0000-0001-9415-4657; 66180
dc.information.autorucFacultad de Ciencias Biológicas; Barrera Vásquez, Aldo Vincent; S/I; 1031200
dc.information.autorucEscuela de Medicina; Budnik Ojeda, Isolda Cecilia; S/I; 209553
dc.information.autorucEscuela de Medicina; Medina, Rafael; 0000-0002-5013-6884; 1000649
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaNature Communications
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBacterial pneumonia
dc.subjectPandemic influenza
dc.subjectAirway microbiota
dc.subjectMortality
dc.subjectFerret
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMicrobiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection
dc.typeartículo
dc.volumen11
sipa.codpersvinculados245038
sipa.codpersvinculados66180
sipa.codpersvinculados1031200
sipa.codpersvinculados209553
sipa.codpersvinculados1000649
sipa.trazabilidadWOS;05-06-2021
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41467-020-16429-9.pdf
Size:
1.03 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas