A global research priority agenda to advance public health responses to fatty liver disease

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dc.contributor.authorLazarus, Jeffrey V.
dc.contributor.authorMark, Henry E.
dc.contributor.authorAllen, Alina M.
dc.contributor.authorArab, Juan Pablo
dc.contributor.authorCarrieri, Patrizia
dc.contributor.authorNoureddin, Mazen
dc.contributor.authorAlazawi, William
dc.contributor.authorAlkhouri, Naim
dc.contributor.authorAlqahtani, Saleh A.
dc.contributor.authorArrese, Marco
dc.contributor.authorBataller, Ramon
dc.contributor.authorBerg, Thomas
dc.contributor.authorBrennan, Paul N.
dc.contributor.authorBurra, Patrizia
dc.contributor.authorCastro-Narro, Graciela E.
dc.contributor.authorCortez-Pinto, Helena
dc.contributor.authorCusi, Kenneth
dc.contributor.authorDedes, Nikos
dc.contributor.authorDuseja, Ajay
dc.contributor.authorFrancque, Sven M.
dc.contributor.authorHagstrom, Hannes
dc.contributor.authorHuang, Terry T. -K.
dc.contributor.authorWajcman, Dana Ivancovsky
dc.contributor.authorKautz, Achim
dc.contributor.authorKopka, Christopher J.
dc.contributor.authorKrag, Aleksander
dc.contributor.authorMiller, Veronica
dc.contributor.authorNewsome, Philip N.
dc.contributor.authorRinella, Mary E.
dc.contributor.authorRomero, Diana
dc.contributor.authorSarin, Shiv Kumar
dc.contributor.authorSilva, Marcelo
dc.contributor.authorSpearman, C. Wendy
dc.contributor.authorTsochatzis, Emmanuel A.
dc.contributor.authorValenti, Luca
dc.contributor.authorVillota-Rivas, Marcela
dc.contributor.authorZelber-Sagi, Shira
dc.contributor.authorSchattenberg, Jorn M.
dc.contributor.authorWong, Vincent Wai-Sun
dc.contributor.authorYounossi, Zobair M.
dc.date.accessioned2025-01-20T17:32:02Z
dc.date.available2025-01-20T17:32:02Z
dc.date.issued2023
dc.description.abstractBackground & aims: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community.
dc.description.abstractMethods: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy.
dc.description.abstractResults: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of 'agree' responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement ('agree' + 'somewhat agree'); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% 'agree'), 13 priorities had <80% 'agree', with greater reliance on 'somewhat agree' to achieve >90% combined agreement.
dc.description.abstractConclusions: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community's efforts to advance and accelerate responses to this widespread and fast-growing public health threat. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jhep.2023.04.035
dc.identifier.eissn1600-0641
dc.identifier.issn0168-8278
dc.identifier.urihttps://doi.org/10.1016/j.jhep.2023.04.035
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91619
dc.identifier.wosidWOS:001068901500001
dc.issue.numero3
dc.language.isoen
dc.pagina.final634
dc.pagina.inicio618
dc.revistaJournal of hepatology
dc.rightsacceso restringido
dc.subjectDelphi method
dc.subjectGlobal health
dc.subjectNon-communicable disease (NCD)
dc.subjectNAFLD/NASH
dc.subjectSteatotic liver disease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA global research priority agenda to advance public health responses to fatty liver disease
dc.typeartículo
dc.volumen79
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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