Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome

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dc.catalogadorpau
dc.contributor.authorDougnac Labatut, Alberto
dc.contributor.authorCastro López, Ricardo
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorCalvo, M.
dc.contributor.authorEugenin, E.
dc.contributor.authorArellano, M.
dc.contributor.authorPattillo, A.
dc.contributor.authorRegueira Heskia, Tomás
dc.contributor.authorMercado Flores, Marcelo Esteban
dc.contributor.authorAndresen Hernández, Max Alfonso
dc.date.accessioned2023-07-21T17:46:11Z
dc.date.available2023-07-21T17:46:11Z
dc.date.issued2007
dc.description.abstractPurpose: To study infl ammatory profi le in patients with sepsis, severe sepsis and septic shock with regards to organ dysfunction and outcome, and to identify a pattern associated with more catastrophic course of illness, organ failure and risk of death. Material and methods: Twenty-nine consecutive patients with sepsis admitted to a medical Intensive Care Unit of a tertiary university hospital (November 2002-December 2003). Plasmatic levels of interleukin-6 (IL-6) and interleukin-10 (IL10) as pro-infl ammatory and anti-infl ammatory markers were measured at baseline, 12, 24 and 48 hours of evolution. Results: There is a positive association between higher levels of IL-6 and severity of the septic process, organ dysfunctions and risk of death, statistically signifi cant at anytime (at baseline, 12, 24 and 48 hours, p <0.05). Higher IL-6/IL-10 ratios associate signifi cantly with risk of death at 24 hours (RR=1.45 if higher or equal to the median). Conclusions: Plasmatic biomarkers measurement during the initial phase of sepsis may help to individualize therapy. An evaluation at 24 h based on IL-6/IL-10 ratio may anticipate a more aggressive infl ammatory profi le. These patients would specially benefi t from immunomodulating therapies to improve survival.
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.issn1410-7767
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-34547662425&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74254
dc.information.autorucEscuela de Medicina; Dougnac Labatut, Alberto; S/I; 54554
dc.information.autorucEscuela de Medicina; Castro López, Ricardo; 0000-0002-0978-9891; 4537
dc.information.autorucEscuela de Medicina; Regueira Heskia, Tomás; S/I; 18434
dc.information.autorucEscuela de Medicina; Mercado Flores, Marcelo Esteban; S/I; 18889
dc.information.autorucEscuela de Medicina; Andresen Hernández, Max Alfonso; 0000-0003-1874-1416; 54274
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final107
dc.pagina.inicio99
dc.revistaCritical Care and Shockes_ES
dc.rightsacceso abierto
dc.subjectInfl ammation
dc.subjectSepsis
dc.subjectInterleukin
dc.subjectSeverity
dc.subjectOutcome
dc.titlePro- and anti-inflammatory balance of septic patients is associated with severity and outcome
dc.typeartículo
dc.volumen10
sipa.codpersvinculados54554
sipa.codpersvinculados4537
sipa.codpersvinculados18434
sipa.codpersvinculados18889
sipa.codpersvinculados54274
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