Microalgae share key features with human erythrocytes and can safely circulate through the vascular system in mice

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dc.catalogadorjca
dc.contributor.authorEhrenfeld, Carolina
dc.contributor.authorVeloso-Giménez, Valentina
dc.contributor.authorCorrales-Orovio, Rocío
dc.contributor.authorRebolledo, Rolando
dc.contributor.authorBoric, Mauricio P.
dc.contributor.authorEgaña, José Tomás
dc.date.accessioned2024-02-27T16:02:45Z
dc.date.available2024-02-27T16:02:45Z
dc.date.issued2023
dc.description.abstractAs animal cells cannot produce oxygen, erythrocytes are responsible for gas interchange, being able to capture and deliver oxygen upon tissue request. Interestingly, several other cells in nature produce oxygen by photosynthesis, raising the question of whether they could circulate within the vascular networks, acting as an alternative source for oxygen delivery. To address this long-term goal, here some physical and mechanical features of the photosynthetic microalga Chlamydomona reinhardtii were studied and compared with erythrocytes, revealing that both exhibit similar size and rheological properties. Moreover, key biocompatibility aspects of the microalgae were evaluated in vitro and in vivo, showing that C. reinhardtii can be co-cultured with endothelial cells, without affecting each other’s morphology and viability. Moreover, short-term systemic perfusion of the microalgae showed a thoroughly intravascular distribution in mice. Finally, the systemic injection of high numbers of microalgae did not trigger deleterious responses in living mice. Altogether, this work provides key scientific insights to support the notion that photosynthetic oxygenation could be achieved by circulating microalgae, representing another important step towards human photosynthesis.
dc.fuente.origenORCID
dc.identifier.doi10.1007/s00253-023-12588-z
dc.identifier.issn0175-7598
dc.identifier.urihttps://doi.org/10.1007/s00253-023-12588-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81327
dc.identifier.wosidWOS:000995223700004
dc.information.autorucFacultad de Ciencias Biológicas;Ehrenfeld Aranda, Carolina Andrea;S/I;250108
dc.information.autorucEscuela de Ingeniería;Veloso Giménez, Valentina Del Carmen;S/I;1049917
dc.information.autorucInstituto de Ingeniería Biológica y Médica;Rebolledo Acevedo, Rolando Arturo;0000-0003-3501-4042;127520
dc.information.autorucFacultad de Ciencias Biológicas;Boric Pellerano, Mauricio;0000-0001-6735-6675;56355
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Egaña Erazo, Jose Tomas; 0000-0003-2624-6992; 1018715
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final4633
dc.pagina.inicio4621
dc.revistaApplied Microbiology and Biotechnology
dc.rightsacceso restringido
dc.subjectOxygen
dc.subjectMicroalgae
dc.subjectChlamydomonas reinhardtii
dc.subjectBlood perfusion
dc.subjectHuman photosynthesis
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods06 Clean water and sanitation
dc.subject.odspa06 Agua limpia y saneamiento
dc.titleMicroalgae share key features with human erythrocytes and can safely circulate through the vascular system in mice
dc.typeartículo
dc.volumen107
sipa.codpersvinculados250108
sipa.codpersvinculados1049917
sipa.codpersvinculados127520
sipa.codpersvinculados56355
sipa.codpersvinculados1018715
sipa.trazabilidadORCID;2024-01-15
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